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AF4/FMR2 Family, Member 2 (AFF2)

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FMR2; FRAXE; MRX2; OX19; Fragile X Mental Retardation 2; Fragile X E mental retardation syndrome protein

AF4/FMR2 Family, Member 2 (AFF2)
CCC L177
HGNC 3776
MGI 1202294
PubMed 22190500
RGD 1565592
UniProt P51816
Wiki AFF2
AFF2encodes a putative transcriptional activator that is a member of the AF4\FMR2 gene family. This gene is associated with the folate-sensitive fragile X E locus on chromosome X. A repeat polymorphism in the fragile X E locus results in silencing of this gene causing Fragile X E syndrome. The cDNA sequence possessed both a putative start of translation and a poly(A) tail. The predicted protein had amino acid motifs that shared significant homology with the human AF4 gene, which encodes a putative transcription factor. On Northern analysis, the cDNA detected a 9.5-kb transcript in human brain, placenta, and lung. This transcript was present in multiple human brain tissues, but was more abundant in the hippocampus and the amygdala, thus providing possible functional insights.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant AF4/FMR2 Family, Member 2 (AFF2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to AF4/FMR2 Family, Member 2 (AFF2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to AF4/FMR2 Family, Member 2 (AFF2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for AF4/FMR2 Family, Member 2 (AFF2) CLIA Kit Customized Service Offer
n/a ELISA Kit for AF4/FMR2 Family, Member 2 (AFF2) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant AF4/FMR2 Family, Member 2 (AFF2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to AF4/FMR2 Family, Member 2 (AFF2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to AF4/FMR2 Family, Member 2 (AFF2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for AF4/FMR2 Family, Member 2 (AFF2) CLIA Kit Customized Service Offer
n/a ELISA Kit for AF4/FMR2 Family, Member 2 (AFF2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant AF4/FMR2 Family, Member 2 (AFF2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to AF4/FMR2 Family, Member 2 (AFF2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to AF4/FMR2 Family, Member 2 (AFF2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for AF4/FMR2 Family, Member 2 (AFF2) CLIA Kit Customized Service Offer
n/a ELISA Kit for AF4/FMR2 Family, Member 2 (AFF2) ELISA Kit Customized Service Offer
  1. "Identification of the gene FMR2, associated with FRAXE mental retardation."Nat. Genet. 13:105-108(1996) [PubMed] [Europe PMC] [Abstract]
  2. "Identification of FMR2, a novel gene associated with the FRAXE CCG repeat and CpG island."Nat. Genet. 13:109-113(1996) [PubMed] [Europe PMC] [Abstract]
  3. "A candidate gene for mild mental handicap at the FRAXE fragile site."Hum. Mol. Genet. 5:275-282(1996) [PubMed] [Europe PMC] [Abstract]
  4. "Gene structure and subcellular localization of FMR2, a member of a new family of putative transcription activators."Genomics 44:201-213(1997) [PubMed] [Europe PMC] [Abstract]
  5. "Expression of the murine homologue of FMR2 in mouse brain and during development."Hum. Mol. Genet. 7:441-448(1998) [PubMed] [Europe PMC] [Abstract]
  6. "Gene diversity patterns at 10 X-chromosomal loci in humans and chimpanzees."Mol. Biol. Evol. 20:1281-1289(2003) [PubMed] [Europe PMC] [Abstract]
  7. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  8. "The DNA sequence of the human X chromosome." Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
  9. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  10. "FRAXE-associated mental retardation protein (FMR2) is an RNA-binding protein with high affinity for G-quartet RNA forming structure."Nucleic Acids Res. 37:1269-1279(2009) [PubMed] [Europe PMC] [Abstract]
  11. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  12. "Familial intellectual disability and autistic behavior caused by a small FMR2 gene deletion."Am. J. Med. Genet. A 155:2003-2007(2011) [PubMed] [Europe PMC] [Abstract]