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Actin Related Protein 2 (ACTR2)

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ARP2; Actin-like protein 2

Actin Related Protein 2 (ACTR2)
CCC L175
HGNC 169
MGI 1913963
PubMed 15159390
RGD 1310826
UniProt P61160
Wiki ACTR2
The specific function of this gene has not yet been determined; however, the protein it encodes is known to be a major constituent of the ARP2/3 complex. This complex is located at the cell surface and is essential to cell shape and motility through lamellipodial actin assembly and protrusion. Two transcript variants encoding different isoforms have been found for this gene.
The ARP2 cDNA encodes a deduced 394-amino acid protein that is 99% identical to chicken Arp2 and 67% identical to S. cerevisiae Arp2. In addition to 43-kD ARP2 and 50-kD ARP3 (ACTR3), the human complex consists of 41/40- (ARPC1B), 34- (ARPC2), 21- (ARPC3), 20- (ARPC4), and 16-kD (ARPC5) subunits, all present in approximately equal stoichiometry.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Actin Related Protein 2 (ACTR2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Actin Related Protein 2 (ACTR2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Actin Related Protein 2 (ACTR2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Actin Related Protein 2 (ACTR2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Actin Related Protein 2 (ACTR2) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Actin Related Protein 2 (ACTR2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Actin Related Protein 2 (ACTR2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Actin Related Protein 2 (ACTR2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Actin Related Protein 2 (ACTR2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Actin Related Protein 2 (ACTR2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Actin Related Protein 2 (ACTR2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Actin Related Protein 2 (ACTR2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Actin Related Protein 2 (ACTR2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Actin Related Protein 2 (ACTR2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Actin Related Protein 2 (ACTR2) ELISA Kit Customized Service Offer
  1. "The human Arp2/3 complex is composed of evolutionarily conserved subunits and is localized to cellular regions of dynamic actin filament assembly."J. Cell Biol. 138:375-384(1997) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  4. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Actin polymerization is induced by Arp2/3 protein complex at the surface of Listeria monocytogenes."Nature 385:265-269(1997) [PubMed] [Europe PMC] [Abstract]
  7. "Reconstitution of human Arp2/3 complex reveals critical roles of individual subunits in complex structure and activity."Mol. Cell 8:1041-1052(2001) [PubMed] [Europe PMC] [Abstract]
  8. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
  9. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  10. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]