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Actin Related Protein 3 (ACTR3)

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ARP3; Actin-like protein 3

Actin Related Protein 3 (ACTR3)
CCC L174
HGNC 170
MGI 1921367
PubMed 15159390
RGD 71024
UniProt P61158
Wiki ACTR3
The specific function of this gene has not yet been determined; however, the protein it encodes is known to be a major constituent of the ARP2/3 complex. This complex is located at the cell surface and is essential to cell shape and motility through lamellipodial actin assembly and protrusion.
The ARP3 cDNA encodes a deduced 418-amino acid protein that is identical to bovine Arp3, 59% identical to S. pombe Arp3, and 58% identical to S. cerevisiae Arp3. ARP3 localizes to the lamellipodia of stationary and locomoting fibroblasts. It also localizes to the actin tails assembled by moving intracellular Listeria monocytogenes bacteria and to actin clouds surrounding stationary L. monocytogenes. ARP3 was not detected in cellular bundles of actin filaments

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPL174Hu01 Recombinant Actin Related Protein 3 (ACTR3) Positive Control; Immunogen; SDS-PAGE; WB.
RPL174Hu02 Recombinant Actin Related Protein 3 (ACTR3) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAL174Hu01 Polyclonal Antibody to Actin Related Protein 3 (ACTR3) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Actin Related Protein 3 (ACTR3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Actin Related Protein 3 (ACTR3) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Actin Related Protein 3 (ACTR3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Actin Related Protein 3 (ACTR3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Actin Related Protein 3 (ACTR3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Actin Related Protein 3 (ACTR3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Actin Related Protein 3 (ACTR3) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Actin Related Protein 3 (ACTR3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Actin Related Protein 3 (ACTR3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Actin Related Protein 3 (ACTR3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Actin Related Protein 3 (ACTR3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Actin Related Protein 3 (ACTR3) ELISA Kit Customized Service Offer
  1. "The human Arp2/3 complex is composed of evolutionarily conserved subunits and is localized to cellular regions of dynamic actin filament assembly."J. Cell Biol. 138:375-384(1997) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Actin polymerization is induced by Arp2/3 protein complex at the surface of Listeria monocytogenes."Nature 385:265-269(1997) [PubMed] [Europe PMC] [Abstract]
  6. , Submitted (MAY-2006) to UniProtKB
  7. , Submitted (MAR-2007) to UniProtKB
  8. "Reconstitution of human Arp2/3 complex reveals critical roles of individual subunits in complex structure and activity."Mol. Cell 8:1041-1052(2001) [PubMed] [Europe PMC] [Abstract]
  9. "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells."Nat. Biotechnol. 23:94-101(2005) [PubMed] [Europe PMC] [Abstract]
  10. "WHAMM is an Arp2/3 complex activator that binds microtubules and functions in ER to Golgi transport."Cell 134:148-161(2008) [PubMed] [Europe PMC] [Abstract]
  11. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  12. "Pyrin and ASC co-localize to cellular sites that are rich in polymerizing actin."Exp. Biol. Med. (Maywood) 234:40-52(2009) [PubMed] [Europe PMC] [Abstract]
  13. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
  14. "Functional genomic screen for modulators of ciliogenesis and cilium length."Nature 464:1048-1051(2010) [PubMed] [Europe PMC] [Abstract]
  15. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  16. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]