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Acyl Coenzyme A Dehydrogenase Family, Member 9 (ACAD9)

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NPD002

Acyl Coenzyme A Dehydrogenase Family, Member 9 (ACAD9)
CCC L172
HGNC 21497
MGI 1914272
PubMed 21057504
RGD 727973
UniProt Q9H845
Wiki ACAD9
Mitochondrial fatty acid beta-oxidation is one of the main energy-producing metabolic pathways in eukaryotes. Acyl-CoA dehydrogenases (ACADs; EC 1.3.99.13) are mitochondrial enzymes that catalyze the initial rate-limiting step in the beta-oxidation of fatty acyl-CoA. ACAD9 belongs to a group of ACADs that act on fatty acids containing 14 to 20 carbons.The deduced 621-amino acid protein has a calculated molecular mass of 68.8 kD. It has an N-terminal leader sequence, 2 conserved motifs shared by all ACAD family members, and a potential N-glycosylation site. Northern blot analysis detected a 2.6-kb transcript in all tissues examined except peripheral blood leukocytes. ACAD9 is the long-chain acyl-CoA dehydrogenase in human embryonic and fetal brain and central nervous tissue.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Acyl Coenzyme A Dehydrogenase Family, Member 9 (ACAD9) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Acyl Coenzyme A Dehydrogenase Family, Member 9 (ACAD9) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Acyl Coenzyme A Dehydrogenase Family, Member 9 (ACAD9) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Acyl Coenzyme A Dehydrogenase Family, Member 9 (ACAD9) CLIA Kit Customized Service Offer
n/a ELISA Kit for Acyl Coenzyme A Dehydrogenase Family, Member 9 (ACAD9) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Acyl Coenzyme A Dehydrogenase Family, Member 9 (ACAD9) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Acyl Coenzyme A Dehydrogenase Family, Member 9 (ACAD9) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Acyl Coenzyme A Dehydrogenase Family, Member 9 (ACAD9) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Acyl Coenzyme A Dehydrogenase Family, Member 9 (ACAD9) CLIA Kit Customized Service Offer
n/a ELISA Kit for Acyl Coenzyme A Dehydrogenase Family, Member 9 (ACAD9) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Acyl Coenzyme A Dehydrogenase Family, Member 9 (ACAD9) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Acyl Coenzyme A Dehydrogenase Family, Member 9 (ACAD9) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Acyl Coenzyme A Dehydrogenase Family, Member 9 (ACAD9) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Acyl Coenzyme A Dehydrogenase Family, Member 9 (ACAD9) CLIA Kit Customized Service Offer
n/a ELISA Kit for Acyl Coenzyme A Dehydrogenase Family, Member 9 (ACAD9) ELISA Kit Customized Service Offer
  1. "Cloning and functional characterization of ACAD-9, a novel member of human acyl-CoA dehydrogenase family."Biochem. Biophys. Res. Commun. 297:1033-1042(2002) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "A new genetic disorder in mitochondrial fatty acid beta-oxidation: ACAD9 deficiency."Am. J. Hum. Genet. 81:87-103(2007) [PubMed] [Europe PMC] [Abstract]
  5. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
  6. "Acyl-CoA dehydrogenase 9 is required for the biogenesis of oxidative phosphorylation complex I."Cell Metab. 12:283-294(2010) [PubMed] [Europe PMC] [Abstract]
  7. "Exome sequencing identifies ACAD9 mutations as a cause of complex I deficiency."Nat. Genet. 42:1131-1134(2010) [PubMed] [Europe PMC] [Abstract]
  8. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  9. "ACAD9, a complex I assembly factor with a moonlighting function in fatty acid oxidation deficiencies."Hum. Mol. Genet. 23:1311-1319(2014) [PubMed] [Europe PMC] [Abstract]
  10. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  11. "Riboflavin-responsive oxidative phosphorylation complex I deficiency caused by defective ACAD9: new function for an old gene."Brain 134:210-219(2011) [PubMed] [Europe PMC] [Abstract]
  12. "Molecular diagnosis in mitochondrial complex I deficiency using exome sequencing." J. Med. Genet. 49:277-283(2012) [PubMed] [Europe PMC] [Abstract]
  13. "Mitochondrial encephalomyopathy due to a novel mutation in ACAD9."JAMA Neurol. 70:1177-1179(2013) [PubMed] [Europe PMC] [Abstract]
  14. "A patient with complex I deficiency caused by a novel ACAD9 mutation not responding to riboflavin treatment."JIMD Rep. 12:37-45(2014) [PubMed] [Europe PMC] [Abstract]