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NOTCH4 encodes a member of the Notch family. Members of this Type 1 transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple, different domain types.
This protein is cleaved in the trans-Golgi network, and presented on the cell surface as a heterodimer. This protein functions as a receptor for membrane bound ligands, and may play a role in vascular, renal and hepatic development. This gene may be associated with susceptibility to schizophrenia in a small portion of cases. An alternative splice variant has been described but its biological nature has not been determined.
Organism species: Homo sapiens (Human)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPL149Hu01 | Recombinant Notch Homolog 4 (NOTCH4) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | PAL149Hu01 | Polyclonal Antibody to Notch Homolog 4 (NOTCH4) | WB; IHC; ICC; IP. |
| Assay Kits | SEL149Hu | ELISA Kit for Notch Homolog 4 (NOTCH4) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Mus musculus (Mouse)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | n/a | Recombinant Notch Homolog 4 (NOTCH4) | Recombinant Protein Customized Service Offer |
| Antibodies | n/a | Monoclonal Antibody to Notch Homolog 4 (NOTCH4) | Monoclonal Antibody Customized Service Offer |
| n/a | Polyclonal Antibody to Notch Homolog 4 (NOTCH4) | Polyclonal Antibody Customized Service Offer | |
| Assay Kits | n/a | CLIA Kit for Notch Homolog 4 (NOTCH4) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Notch Homolog 4 (NOTCH4) | ELISA Kit Customized Service Offer |
Organism species: Rattus norvegicus (Rat)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPL149Ra01 | Recombinant Notch Homolog 4 (NOTCH4) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | PAL149Ra01 | Polyclonal Antibody to Notch Homolog 4 (NOTCH4) | WB; IHC; ICC; IP. |
| Assay Kits | n/a | CLIA Kit for Notch Homolog 4 (NOTCH4) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Notch Homolog 4 (NOTCH4) | ELISA Kit Customized Service Offer |
- "Gene organization of human NOTCH4 and (CTG)n polymorphism in this human counterpart gene of mouse proto-oncogene Int3."Gene 189:235-244(1997) [PubMed] [Europe PMC] [Abstract]
- "Cloning, characterization, and the complete 56.8-kilobase DNA sequence of the human NOTCH4 gene."Genomics 51:45-58(1998) [PubMed] [Europe PMC] [Abstract]
- "The DNA sequence and analysis of human chromosome 6." Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
- "Human ligands of the Notch receptor."Am. J. Pathol. 154:785-794(1999) [PubMed] [Europe PMC] [Abstract]
- "MAML1, a human homologue of Drosophila mastermind, is a transcriptional co-activator for NOTCH receptors."Nat. Genet. 26:484-489(2000) [PubMed] [Europe PMC] [Abstract]
- "Identification of a family of mastermind-like transcriptional coactivators for mammalian notch receptors."Mol. Cell. Biol. 22:7688-7700(2002) [PubMed] [Europe PMC] [Abstract]