≡

Mutated In Colorectal Cancers (MCC)

[Edit]

Mutated In Colorectal Cancers (MCC)
CCC L145
HGNC 6935
MGI 96930
PubMed 1848370
RGD 1561988
UniProt P23508
Wiki MCC
MCC is a candidate colorectal tumor suppressor gene that is thought to negatively regulate cell cycle progression. The orthologous gene in the mouse expresses a phosphoprotein associated with the plasma membrane and membrane organelles, and overexpression of the mouse protein inhibits entry into S phase. Multiple transcript variants encoding different isoforms have been found for this gene.
Sequence analysis of the cosmid probe encompassing this region revealed a gene encoding a deduced 829-amino acid protein with a short region of similarity to a G protein-coupled M3 muscarinic acetylcholine receptor . The authors called the gene MCC for 'mutated in colorectal cancer.'

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Mutated In Colorectal Cancers (MCC) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Mutated In Colorectal Cancers (MCC) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Mutated In Colorectal Cancers (MCC) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Mutated In Colorectal Cancers (MCC) CLIA Kit Customized Service Offer
n/a ELISA Kit for Mutated In Colorectal Cancers (MCC) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Mutated In Colorectal Cancers (MCC) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Mutated In Colorectal Cancers (MCC) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Mutated In Colorectal Cancers (MCC) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Mutated In Colorectal Cancers (MCC) CLIA Kit Customized Service Offer
n/a ELISA Kit for Mutated In Colorectal Cancers (MCC) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Mutated In Colorectal Cancers (MCC) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Mutated In Colorectal Cancers (MCC) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Mutated In Colorectal Cancers (MCC) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Mutated In Colorectal Cancers (MCC) CLIA Kit Customized Service Offer
n/a ELISA Kit for Mutated In Colorectal Cancers (MCC) ELISA Kit Customized Service Offer
  1. "Identification of a gene located at chromosome 5q21 that is mutated in colorectal cancers."Science 251:1366-1370(1991) [PubMed] [Europe PMC] [Abstract]
  2. "The DNA sequence and comparative analysis of human chromosome 5." Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Mutated in colorectal cancer, a putative tumor suppressor for serrated colorectal cancer, selectively represses beta-catenin-dependent transcription."Oncogene 27:6044-6055(2008) [PubMed] [Europe PMC] [Abstract]
  6. "MCC, a new interacting protein for Scrib, is required for cell migration in epithelial cells."FEBS Lett. 583:2326-2332(2009) [PubMed] [Europe PMC] [Abstract]
  7. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  8. "The PDZ-binding motif of MCC is phosphorylated at position -1 and controls lamellipodia formation in colon epithelial cells."Biochim. Biophys. Acta 1823:1058-1067(2012) [PubMed] [Europe PMC] [Abstract]
  9. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  10. "Mutations of chromosome 5q21 genes in FAP and colorectal cancer patients." Science 253:665-669(1991) [PubMed] [Europe PMC] [Abstract]