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GLE1 RNA Export Mediator Like Protein (GLE1L)

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GLE1L; LCCS1; Lethal Congenital Contracture Syndrome 1; Nucleoporin GLE1

GLE1 RNA Export Mediator Like Protein (GLE1L)
CCC L137
HGNC 4315
MGI 1921662
PubMed 9618489
RGD 1307329
UniProt Q53GS7
Wiki GLE1L
GLE1Lencodes a predicted 75-kDa polypeptide with high sequence and structure homology to yeast Gle1p, which is nuclear protein with a leucine-rich nuclear export sequence essential for poly(A)+RNA export.
Inhibition of human GLE1L by microinjection of antibodies against GLE1L in HeLa cells resulted in inhibition of poly(A)+RNA export. Immunoflourescence studies show that GLE1L is localized at the nuclear pore complexes. This localization suggests that GLE1L may act at a terminal step in the export of mature RNA messages to the cytoplasm. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant GLE1 RNA Export Mediator Like Protein (GLE1L) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to GLE1 RNA Export Mediator Like Protein (GLE1L) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to GLE1 RNA Export Mediator Like Protein (GLE1L) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for GLE1 RNA Export Mediator Like Protein (GLE1L) CLIA Kit Customized Service Offer
n/a ELISA Kit for GLE1 RNA Export Mediator Like Protein (GLE1L) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant GLE1 RNA Export Mediator Like Protein (GLE1L) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to GLE1 RNA Export Mediator Like Protein (GLE1L) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to GLE1 RNA Export Mediator Like Protein (GLE1L) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for GLE1 RNA Export Mediator Like Protein (GLE1L) CLIA Kit Customized Service Offer
n/a ELISA Kit for GLE1 RNA Export Mediator Like Protein (GLE1L) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant GLE1 RNA Export Mediator Like Protein (GLE1L) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to GLE1 RNA Export Mediator Like Protein (GLE1L) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to GLE1 RNA Export Mediator Like Protein (GLE1L) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for GLE1 RNA Export Mediator Like Protein (GLE1L) CLIA Kit Customized Service Offer
n/a ELISA Kit for GLE1 RNA Export Mediator Like Protein (GLE1L) ELISA Kit Customized Service Offer
  1. "The human homologue of Saccharomyces cerevisiae Gle1p is required for poly(A)+ RNA export."Proc. Natl. Acad. Sci. U.S.A. 95:6779-6784(1998) [PubMed] [Europe PMC] [Abstract]
  2. "DNA sequence and analysis of human chromosome 9." Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  5. "An essential role for hGle1 nucleocytoplasmic shuttling in mRNA export."J. Cell Biol. 160:1029-1040(2003) [PubMed] [Europe PMC] [Abstract]
  6. "The mRNA export factor human Gle1 interacts with the nuclear pore complex protein Nup155."Mol. Cell. Proteomics 3:145-155(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Interaction between the shuttling mRNA export factor Gle1 and the nucleoporin hCG1: a conserved mechanism in the export of Hsp70 mRNA."Mol. Biol. Cell 16:4304-4315(2005) [PubMed] [Europe PMC] [Abstract]
  8. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  9. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  10. "Mutations in mRNA export mediator GLE1 result in a fetal motoneuron disease."Nat. Genet. 40:155-157(2008) [PubMed] [Europe PMC] [Abstract]