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Chemokine C-C-Motif Ligand 4 Like Protein 2 (CCL4L2)

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LAG1; SCYA4L; Lymphocyte activation gene 1; Macrophage inflammatory protein 1-beta; Monocyte adherence-induced protein 5-alpha; Small-inducible cytokine A4-like

Chemokine C-C-Motif Ligand 4 Like Protein 2 (CCL4L2)
CCC L136
HGNC 24066
PubMed 24727646
UniProt Q50EM6
CCL4L2 is one of several cytokine genes clustered on the q-arm of chromosome 17. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. This protein is similar to CCL4 which inhibits HIV entry by binding to the cellular receptor CCR5. The copy number of this gene varies among individuals; most individuals have 1-5 copies in the diploid genome, although rare individuals do not contain this gene at all. The human genome reference assembly contains two copies of this gene. This record represents the more telomeric gene.
CCL4L2 is a telomeric copy of the CCL4L1 gene. By sequencing a BAC clone located in a segmental duplication at chromosome 17q12, Modi (2004) identified 2 complete copies of the CCL3L1 and CCL4L1 genes.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Chemokine C-C-Motif Ligand 4 Like Protein 2 (CCL4L2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Chemokine C-C-Motif Ligand 4 Like Protein 2 (CCL4L2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Chemokine C-C-Motif Ligand 4 Like Protein 2 (CCL4L2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Chemokine C-C-Motif Ligand 4 Like Protein 2 (CCL4L2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Chemokine C-C-Motif Ligand 4 Like Protein 2 (CCL4L2) ELISA Kit Customized Service Offer
  1. "Multiple products derived from two CCL4 loci: high incidence of a new polymorphism in HIV+ patients."J. Immunol. 174:5655-5664(2005) [PubMed] [Europe PMC] [Abstract]
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The human MIP-1beta chemokine is encoded by two paralogous genes, ACT-2 and LAG-1."Immunogenetics 53:543-549(2001) [PubMed] [Europe PMC] [Abstract]
  4. "Functional redundancy of the human CCL4 and CCL4L1 chemokine genes."Biochem. Biophys. Res. Commun. 320:927-931(2004) [PubMed] [Europe PMC] [Abstract]
  5. "CCL3L1 and CCL4L1 chemokine genes are located in a segmental duplication at chromosome 17q12."Genomics 83:735-738(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Independent expression of the two paralogous CCL4 genes in monocytes and B lymphocytes."Immunogenetics 55:706-711(2004) [PubMed] [Europe PMC] [Abstract]
  7. "CCL3L1 and CCL4L1: variable gene copy number in adolescents with and without human immunodeficiency virus type 1 (HIV-1) infection."Genes Immun. 8:224-231(2007) [PubMed] [Europe PMC] [Abstract]