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CDGSH Iron Sulfur Domain Protein 1 (CISD1)

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ZCD1; mitoNEET; C10orf70; Zinc Finger,CDGSH-Type Domain 1

CDGSH Iron Sulfur Domain Protein 1 (CISD1)
CCC L121
HGNC 30880
MGI 1261855
RGD 1309529
UniProt Q9NZ45
CISD1 is a member of the CDGSH domain-containing family and may play a role in the regulation of mitochondrial oxidative capacity. The deduced 108-amino acid protein has a calculated molecular mass of 12.2 kD and contains an N-terminal signal sequence and a C-terminal CDGSH domain, flanked by 2 additional cysteines. The CDGSH domain contains a consensus sequence shared by CISD1, CISD2, and CISD3 . Immunofluorescence studies localized CISD1 to the mitochondria. RT-PCR analysis of mouse tissues detected ubiquitous expression with highest expression in heart. Immunohistochemical staining of mouse tissues detected Cisd1 in many tissues, including liver, adipose tissue, skeletal muscle, and heart. Staining was particularly intense in cells lining the ducts and ventricles.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant CDGSH Iron Sulfur Domain Protein 1 (CISD1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to CDGSH Iron Sulfur Domain Protein 1 (CISD1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to CDGSH Iron Sulfur Domain Protein 1 (CISD1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for CDGSH Iron Sulfur Domain Protein 1 (CISD1) CLIA Kit Customized Service Offer
n/a ELISA Kit for CDGSH Iron Sulfur Domain Protein 1 (CISD1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant CDGSH Iron Sulfur Domain Protein 1 (CISD1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to CDGSH Iron Sulfur Domain Protein 1 (CISD1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to CDGSH Iron Sulfur Domain Protein 1 (CISD1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for CDGSH Iron Sulfur Domain Protein 1 (CISD1) CLIA Kit Customized Service Offer
n/a ELISA Kit for CDGSH Iron Sulfur Domain Protein 1 (CISD1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant CDGSH Iron Sulfur Domain Protein 1 (CISD1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to CDGSH Iron Sulfur Domain Protein 1 (CISD1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to CDGSH Iron Sulfur Domain Protein 1 (CISD1) Polyclonal Antibody Customized Service Offer
Assay Kits SEL121Ra ELISA Kit for CDGSH Iron Sulfur Domain Protein 1 (CISD1) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "CISD1 codifies a mitochondrial protein upregulated by the CFTR channel."Biochem. Biophys. Res. Commun. 365:856-862(2008) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The outer mitochondrial membrane protein mitoNEET contains a novel redox-active 2Fe-2S cluster."J. Biol. Chem. 282:23745-23749(2007) [PubMed] [Europe PMC] [Abstract]
  5. "MitoNEET is an iron-containing outer mitochondrial membrane protein that regulates oxidative capacity."Proc. Natl. Acad. Sci. U.S.A. 104:5318-5323(2007) [PubMed] [Europe PMC] [Abstract]
  6. "Crystal structure of Miner1: The redox-active 2Fe-2S protein causative in Wolfram Syndrome 2."J. Mol. Biol. 392:143-153(2009) [PubMed] [Europe PMC] [Abstract]
  7. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  8. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
  9. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  10. "USP30 and parkin homeostatically regulate atypical ubiquitin chains on mitochondria."Nat. Cell Biol. 17:160-169(2015) [PubMed] [Europe PMC] [Abstract]
  11. "Crystallographic studies of human MitoNEET."J. Biol. Chem. 282:33242-33246(2007) [PubMed] [Europe PMC] [Abstract]
  12. "MitoNEET is a uniquely folded 2Fe 2S outer mitochondrial membrane protein stabilized by pioglitazone."Proc. Natl. Acad. Sci. U.S.A. 104:14342-14347(2007) [PubMed] [Europe PMC] [Abstract]
  13. "Crystal structure of human mitoNEET reveals distinct groups of iron sulfur proteins."Proc. Natl. Acad. Sci. U.S.A. 104:14640-14645(2007) [PubMed] [Europe PMC] [Abstract]