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Sodium Channel Voltage Gated Type IX Alpha (SCN9a)

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NENA; PN1; ETHA; Nav1.7; NE-NA; Neuroendocrine sodium channel; Peripheral sodium channel 1; Voltage-gated sodium channel subunit alpha Nav1.7

Sodium Channel Voltage Gated Type IX Alpha (SCN9a)
CCC L099
HGNC 10597
MGI 107636
PubMed 18060017
RGD 69368
UniProt Q15858
Wiki Nav1.7
NENA, which they designated NE for neuroendocrine channel, was expressed in the same tissues as rat PN1 (peripheral sodium channel-1), including dorsal root ganglia, adrenal, and thyroid tissue. Neither rat PN1 nor human NE was expressed in skeletal muscle.Sequence analysis revealed that the cDNA encodes a 1,977-amino acid polypeptide (Nav1.7) composed of 4 domains, each with 6 transmembrane domains and 2 highly conserved pore-forming segments. The sequence is highly similar to brain and skeletal muscle voltage-gated sodium channels; the authors stated that this channel represents an evolutionary link between sodium channels found in brain and skeletal muscle. Northern blot analysis detected 9.4- and 7.0-kb NENA transcripts in a human C-cell carcinoma cell line.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Sodium Channel Voltage Gated Type IX Alpha (SCN9a) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Sodium Channel Voltage Gated Type IX Alpha (SCN9a) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Sodium Channel Voltage Gated Type IX Alpha (SCN9a) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Sodium Channel Voltage Gated Type IX Alpha (SCN9a) CLIA Kit Customized Service Offer
n/a ELISA Kit for Sodium Channel Voltage Gated Type IX Alpha (SCN9a) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Sodium Channel Voltage Gated Type IX Alpha (SCN9a) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Sodium Channel Voltage Gated Type IX Alpha (SCN9a) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Sodium Channel Voltage Gated Type IX Alpha (SCN9a) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Sodium Channel Voltage Gated Type IX Alpha (SCN9a) CLIA Kit Customized Service Offer
n/a ELISA Kit for Sodium Channel Voltage Gated Type IX Alpha (SCN9a) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Sodium Channel Voltage Gated Type IX Alpha (SCN9a) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Sodium Channel Voltage Gated Type IX Alpha (SCN9a) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Sodium Channel Voltage Gated Type IX Alpha (SCN9a) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Sodium Channel Voltage Gated Type IX Alpha (SCN9a) CLIA Kit Customized Service Offer
n/a ELISA Kit for Sodium Channel Voltage Gated Type IX Alpha (SCN9a) ELISA Kit Customized Service Offer
  1. "Structure and functional expression of a new member of the tetrodotoxin-sensitive voltage-activated sodium channel family from human neuroendocrine cells."EMBO J. 14:1084-1090(1995) [PubMed] [Europe PMC] [Abstract]
  2. "An SCN9A channelopathy causes congenital inability to experience pain."Nature 444:894-898(2006) [PubMed] [Europe PMC] [Abstract]
  3. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
  4. "Expression of alternatively spliced sodium channel alpha-subunit genes: unique splicing patterns are observed in dorsal root ganglia."J. Biol. Chem. 279:46234-46241(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Mutations in SCN9A, encoding a sodium channel alpha subunit, in patients with primary erythermalgia."J. Med. Genet. 41:171-174(2004) [PubMed] [Europe PMC] [Abstract]
  6. "A novel tetrodotoxin-sensitive, voltage-gated sodium channel expressed in rat and human dorsal root ganglia."J. Biol. Chem. 272:14805-14809(1997) [PubMed] [Europe PMC] [Abstract]
  7. "Voltage-gated sodium channel expressed in cultured human smooth muscle cells: involvement of SCN9A."FEBS Lett. 567:339-343(2004) [PubMed] [Europe PMC] [Abstract]
  8. "Electrophysiological properties of mutant Nav1.7 sodium channels in a painful inherited neuropathy."J. Neurosci. 24:8232-8236(2004) [PubMed] [Europe PMC] [Abstract]
  9. "Autosomal dominant erythermalgia associated with a novel mutation in the voltage-gated sodium channel alpha subunit Nav1.7."Arch. Neurol. 62:1587-1590(2005) [PubMed] [Europe PMC] [Abstract]
  10. "Gain-of-function mutation in Nav1.7 in familial erythromelalgia induces bursting of sensory neurons."Brain 128:1847-1854(2005) [PubMed] [Europe PMC] [Abstract]
  11. "SCN9A mutations define primary erythermalgia as a neuropathic disorder of voltage gated sodium channels."J. Invest. Dermatol. 124:1333-1338(2005) [PubMed] [Europe PMC] [Abstract]
  12. "Sporadic onset of erythermalgia: a gain-of-function mutation in Nav1.7."Ann. Neurol. 59:553-558(2006) [PubMed] [Europe PMC] [Abstract]
  13. "Inherited erythermalgia: limb pain from an S4 charge-neutral Na channelopathy."Neurology 67:1563-1567(2006) [PubMed] [Europe PMC] [Abstract]
  14. "SCN9A mutations in paroxysmal extreme pain disorder: allelic variants underlie distinct channel defects and phenotypes."Neuron 52:767-774(2006) [PubMed] [Europe PMC] [Abstract]
  15. "A single sodium channel mutation produces hyper- or hypoexcitability in different types of neurons."Proc. Natl. Acad. Sci. U.S.A. 103:8245-8250(2006) [PubMed] [Europe PMC] [Abstract]
  16. "NaV1.7 gain-of-function mutations as a continuum: A1632E displays physiological changes associated with erythromelalgia and paroxysmal extreme pain disorder mutations and produces symptoms of both disorders."J. Neurosci. 28:11079-11088(2008) [PubMed] [Europe PMC] [Abstract]
  17. "Early- and late-onset inherited erythromelalgia: genotype-phenotype correlation."Brain 132:1711-1722(2009) [PubMed] [Europe PMC] [Abstract]
  18. "A role of SCN9A in human epilepsies, as a cause of febrile seizures and as a potential modifier of Dravet syndrome."PLoS Genet. 5:E1000649-E1000649(2009) [PubMed] [Europe PMC] [Abstract]
  19. "Congenital insensitivity to pain: novel SCN9A missense and in-frame deletion mutations."Hum. Mutat. 31:E1670-E1686(2010) [PubMed] [Europe PMC] [Abstract]
  20. "p.L1612P, a novel voltage-gated sodium channel Nav1.7 mutation inducing a cold sensitive paroxysmal extreme pain disorder."Anesthesiology 122:414-423(2015) [PubMed] [Europe PMC] [Abstract]
  21. "Inherited pain: sodium channel Nav1.7 A1632T mutation causes erythromelalgia due to a shift of fast inactivation."J. Biol. Chem. 289:1971-1980(2014) [PubMed] [Europe PMC] [Abstract]