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WW Domain Containing E3 Ubiquitin Protein Ligase 1 (WWP1)

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AIP5; Tiul1; hSDRP1; NEDD4-like E3 ubiquitin-protein ligase WWP1; Atrophin-1-interacting protein 5; TGIF-interacting ubiquitin ligase 1

WW Domain Containing E3 Ubiquitin Protein Ligase 1 (WWP1)
CCC L088
HGNC 17004
MGI 1861728
PubMed 23293026
RGD 1311734
UniProt Q9H0M0
Wiki WWP1
WW domain-containing proteins are found in all eukaryotes and play an important role in the regulation of a wide variety of cellular functions such as protein degradation, transcription, and RNA splicing.
WWP1 encodes a protein which contains 4 tandem WW domains and a HECT (homologous to the E6-associated protein carboxyl terminus) domain. The encoded protein belongs to a family of NEDD4-like proteins, which are E3 ubiquitin-ligase molecules and regulate key trafficking decisions, including targeting of proteins to proteosomes or lysosomes. Alternative splicing of this gene generates at least 6 transcript variants; however, the full length nature of these transcripts has not been defined.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant WW Domain Containing E3 Ubiquitin Protein Ligase 1 (WWP1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to WW Domain Containing E3 Ubiquitin Protein Ligase 1 (WWP1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to WW Domain Containing E3 Ubiquitin Protein Ligase 1 (WWP1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for WW Domain Containing E3 Ubiquitin Protein Ligase 1 (WWP1) CLIA Kit Customized Service Offer
n/a ELISA Kit for WW Domain Containing E3 Ubiquitin Protein Ligase 1 (WWP1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant WW Domain Containing E3 Ubiquitin Protein Ligase 1 (WWP1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to WW Domain Containing E3 Ubiquitin Protein Ligase 1 (WWP1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to WW Domain Containing E3 Ubiquitin Protein Ligase 1 (WWP1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for WW Domain Containing E3 Ubiquitin Protein Ligase 1 (WWP1) CLIA Kit Customized Service Offer
n/a ELISA Kit for WW Domain Containing E3 Ubiquitin Protein Ligase 1 (WWP1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant WW Domain Containing E3 Ubiquitin Protein Ligase 1 (WWP1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to WW Domain Containing E3 Ubiquitin Protein Ligase 1 (WWP1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to WW Domain Containing E3 Ubiquitin Protein Ligase 1 (WWP1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for WW Domain Containing E3 Ubiquitin Protein Ligase 1 (WWP1) CLIA Kit Customized Service Offer
n/a ELISA Kit for WW Domain Containing E3 Ubiquitin Protein Ligase 1 (WWP1) ELISA Kit Customized Service Offer
  1. "Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs." Genome Res. 11:422-435(2001) [PubMed] [Europe PMC] [Abstract]
  2. "Alternative splicing determines the domain structure of WWP1, a Nedd4 family protein."Biochem. Biophys. Res. Commun. 290:431-437(2002) [PubMed] [Europe PMC] [Abstract]
  3. "The novel E3 ubiquitin ligase Tiul1 associates with TGIF to target Smad2 for degradation."EMBO J. 23:3780-3792(2004) [PubMed] [Europe PMC] [Abstract]
  4. "DNA sequence and analysis of human chromosome 8." Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Identification of novel human WW domain-containing proteins by cloning of ligand targets."J. Biol. Chem. 272:14611-14616(1997) [PubMed] [Europe PMC] [Abstract]
  7. "Atrophin-1, the DRPLA gene product, interacts with two families of WW domain-containing proteins."Mol. Cell. Neurosci. 11:149-160(1998) [PubMed] [Europe PMC] [Abstract]
  8. "Adenovirus protein involved in virus internalization recruits ubiquitin-protein ligases."Biochemistry 41:14299-14305(2002) [PubMed] [Europe PMC] [Abstract]
  9. "Negative regulation of transforming growth factor-beta (TGF-beta) signaling by WW domain-containing protein 1 (WWP1)."Oncogene 23:6914-6923(2004) [PubMed] [Europe PMC] [Abstract]
  10. "The WW domain containing E3 ubiquitin protein ligase 1 upregulates ErbB2 and EGFR through RING finger protein 11."Oncogene 27:6845-6855(2008) [PubMed] [Europe PMC] [Abstract]
  11. "Endogenous spartin (SPG20) is recruited to endosomes and lipid droplets and interacts with the ubiquitin E3 ligases AIP4 and AIP5."Biochem. J. 423:31-39(2009) [PubMed] [Europe PMC] [Abstract]
  12. "Control of the activity of WW-HECT domain E3 ubiquitin ligases by NDFIP proteins."EMBO Rep. 10:501-507(2009) [PubMed] [Europe PMC] [Abstract]
  13. "WW domain containing E3 ubiquitin protein ligase 1 targets the full-length ErbB4 for ubiquitin-mediated degradation in breast cancer."Oncogene 28:2948-2958(2009) [PubMed] [Europe PMC] [Abstract]
  14. "Conformational flexibility underlies ubiquitin ligation mediated by the WWP1 HECT domain E3 ligase."Mol. Cell 11:249-259(2003) [PubMed] [Europe PMC] [Abstract]