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Smad Specific E3 Ubiquitin Protein Ligase 2 (SMURF2)

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SMAD ubiquitination regulatory factor 2; E3 ubiquitin-protein ligase SMURF2

Smad Specific E3 Ubiquitin Protein Ligase 2 (SMURF2)
CCC L082
HGNC 16809
MGI 1913563
PubMed 11016919
RGD 1310067
UniProt Q9HAU4
Wiki SMURF2
SMURF2, a 748-amino acid ubiquitin E3 ligase that is 83% identical to SMURF1.SMURF2 was nuclear, but binding to SMAD7 induced export and recruitment to the activated transforming growth factor-beta receptor (TGFBR), where it caused degradation of receptors and of SMAD7 via proteasomal and lysosomal pathways. Gamma-interferon (IFNG), which stimulates expression of SMAD7, induced SMAD7-SMURF2 complex formation and increased TGFBR turnover, which was stabilized by blocking SMAD7 or SMURF2 expression. Furthermore, SMAD7 mutants that interfered with recruitment of SMURF2 to the receptors were compromised in their inhibitory activity. These studies defined SMAD7 as an adaptor in an E3 ubiquitin ligase complex that targets TGFBR for degradation.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Smad Specific E3 Ubiquitin Protein Ligase 2 (SMURF2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Smad Specific E3 Ubiquitin Protein Ligase 2 (SMURF2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Smad Specific E3 Ubiquitin Protein Ligase 2 (SMURF2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Smad Specific E3 Ubiquitin Protein Ligase 2 (SMURF2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Smad Specific E3 Ubiquitin Protein Ligase 2 (SMURF2) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Smad Specific E3 Ubiquitin Protein Ligase 2 (SMURF2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Smad Specific E3 Ubiquitin Protein Ligase 2 (SMURF2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Smad Specific E3 Ubiquitin Protein Ligase 2 (SMURF2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Smad Specific E3 Ubiquitin Protein Ligase 2 (SMURF2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Smad Specific E3 Ubiquitin Protein Ligase 2 (SMURF2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Smad Specific E3 Ubiquitin Protein Ligase 2 (SMURF2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Smad Specific E3 Ubiquitin Protein Ligase 2 (SMURF2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Smad Specific E3 Ubiquitin Protein Ligase 2 (SMURF2) Polyclonal Antibody Customized Service Offer
Assay Kits SEL082Ra ELISA Kit for Smad Specific E3 Ubiquitin Protein Ligase 2 (SMURF2) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "Smad7 binds to Smurf2 to form an E3 ubiquitin ligase that targets the TGF-beta receptor for degradation."Mol. Cell 6:1365-1375(2000) [PubMed] [Europe PMC] [Abstract]
  2. "Smurf2 Is a ubiquitin E3 ligase mediating proteasome-dependent degradation of Smad2 in transforming growth factor-beta signaling."J. Biol. Chem. 275:36818-36822(2000) [PubMed] [Europe PMC] [Abstract]
  3. "Regulation of Smad degradation and activity by Smurf2, an E3 ubiquitin ligase."Proc. Natl. Acad. Sci. U.S.A. 98:974-979(2001) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "TGF-beta induces assembly of a Smad2-Smurf2 ubiquitin ligase complex that targets SnoN for degradation."Nat. Cell Biol. 3:587-595(2001) [PubMed] [Europe PMC] [Abstract]
  6. "Distinct endocytic pathways regulate TGF-beta receptor signalling and turnover."Nat. Cell Biol. 5:410-421(2003) [PubMed] [Europe PMC] [Abstract]
  7. ErratumNat. Cell Biol. 5:680-680(2003)
  8. "The RING-H2 protein RNF11 is overexpressed in breast cancer and is a target of Smurf2 E3 ligase."Br. J. Cancer 89:1538-1544(2003) [PubMed] [Europe PMC] [Abstract]
  9. "An RNF11: Smurf2 complex mediates ubiquitination of the AMSH protein."Oncogene 23:1801-1808(2004) [PubMed] [Europe PMC] [Abstract]
  10. "AIMP1/p43 downregulates TGF-beta signaling via stabilization of smurf2."Biochem. Biophys. Res. Commun. 371:395-400(2008) [PubMed] [Europe PMC] [Abstract]
  11. "Control of the activity of WW-HECT domain E3 ubiquitin ligases by NDFIP proteins."EMBO Rep. 10:501-507(2009) [PubMed] [Europe PMC] [Abstract]
  12. "SCF(FBXL15) regulates BMP signalling by directing the degradation of HECT-type ubiquitin ligase Smurf1."EMBO J. 30:2675-2689(2011) [PubMed] [Europe PMC] [Abstract]
  13. "Regulation of Smurf2 ubiquitin ligase activity by anchoring the E2 to the HECT domain."Mol. Cell 19:297-308(2005) [PubMed] [Europe PMC] [Abstract]
  14. "An expanded WW domain recognition motif revealed by the interaction between Smad7 and the E3 ubiquitin ligase Smurf2."J. Biol. Chem. 281:17069-17075(2006) [PubMed] [Europe PMC] [Abstract]
  15. "Autoinhibition of the HECT-type ubiquitin ligase Smurf2 through its C2 domain."Cell 130:651-662(2007) [PubMed] [Europe PMC] [Abstract]