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HECT Domain And RCC1 Like Domain Protein 2 (HERC2)

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jdf2; p528; E3 ubiquitin-protein ligase HERC2

HECT Domain And RCC1 Like Domain Protein 2 (HERC2)
CCC L078
HGNC 4868
MGI 103234
PubMed 20631078
RGD 1307989
UniProt O95714
Wiki HERC2
Sequence analysis predicted that the 4,834-amino acid protein, which is 95% identical and 99% similar to the mouse protein, contains 3 RCC1-like domains (RLDs); a putative ZZ-type zinc finger motif with 6 conserved cysteines and 2 outlying histidine residues; a C-terminal HECT or E3 ubiquitin ligase domain; and several potential phosphorylation sites. The overall structure is similar to that of HERC1, although HERC1 has only 2 RLDs and no zinc finger motif. The C-terminal region of HERC2 resembles that of HERC3.
Northern blot analysis revealed ubiquitous expression of a 15.5-kb HERC2 transcript, with high levels in fetal tissues and adult skeletal muscle, heart, ovary, testis, and brain.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant HECT Domain And RCC1 Like Domain Protein 2 (HERC2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to HECT Domain And RCC1 Like Domain Protein 2 (HERC2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to HECT Domain And RCC1 Like Domain Protein 2 (HERC2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for HECT Domain And RCC1 Like Domain Protein 2 (HERC2) CLIA Kit Customized Service Offer
n/a ELISA Kit for HECT Domain And RCC1 Like Domain Protein 2 (HERC2) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant HECT Domain And RCC1 Like Domain Protein 2 (HERC2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to HECT Domain And RCC1 Like Domain Protein 2 (HERC2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to HECT Domain And RCC1 Like Domain Protein 2 (HERC2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for HECT Domain And RCC1 Like Domain Protein 2 (HERC2) CLIA Kit Customized Service Offer
n/a ELISA Kit for HECT Domain And RCC1 Like Domain Protein 2 (HERC2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant HECT Domain And RCC1 Like Domain Protein 2 (HERC2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to HECT Domain And RCC1 Like Domain Protein 2 (HERC2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to HECT Domain And RCC1 Like Domain Protein 2 (HERC2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for HECT Domain And RCC1 Like Domain Protein 2 (HERC2) CLIA Kit Customized Service Offer
n/a ELISA Kit for HECT Domain And RCC1 Like Domain Protein 2 (HERC2) ELISA Kit Customized Service Offer
  1. "The ancestral gene for transcribed, low-copy repeats in the Prader-Willi/Angelman region encodes a large protein implicated in protein trafficking, which is deficient in mice with neuromuscular and spermiogenic abnormalities."Hum. Mol. Genet. 8:533-542(1999) [PubMed] [Europe PMC] [Abstract]
  2. "Analysis of the DNA sequence and duplication history of human chromosome 15." Nature 440:671-675(2006) [PubMed] [Europe PMC] [Abstract]
  3. "Structure of the highly conserved HERC2 gene and of multiple partially duplicated paralogs in human."Genome Res. 10:319-329(2000) [PubMed] [Europe PMC] [Abstract]
  4. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  5. "Three genome-wide association studies and a linkage analysis identify HERC2 as a human iris color gene." Am. J. Hum. Genet. 82:411-423(2008) [PubMed] [Europe PMC] [Abstract]
  6. "A single SNP in an evolutionary conserved region within intron 86 of the HERC2 gene determines human blue-brown eye color."Am. J. Hum. Genet. 82:424-431(2008) [PubMed] [Europe PMC] [Abstract]
  7. "Blue eye color in humans may be caused by a perfectly associated founder mutation in a regulatory element located within the HERC2 gene inhibiting OCA2 expression."Hum. Genet. 123:177-187(2008) [PubMed] [Europe PMC] [Abstract]
  8. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  9. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  10. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  11. "Human eye colour and HERC2, OCA2 and MATP."Forensic Sci. Int. Genet. 4:323-328(2010) [PubMed] [Europe PMC] [Abstract]
  12. "HERC2 coordinates ubiquitin-dependent assembly of DNA repair factors on damaged chromosomes."Nat. Cell Biol. 12:80-86(2010) [PubMed] [Europe PMC] [Abstract]
  13. "Circadian control of XPA and excision repair of cisplatin-DNA damage by cryptochrome and HERC2 ubiquitin ligase."Proc. Natl. Acad. Sci. U.S.A. 107:4890-4895(2010) [PubMed] [Europe PMC] [Abstract]
  14. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  15. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  16. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  17. "DNA damage-inducible SUMOylation of HERC2 promotes RNF8 binding via a novel SUMO-binding Zinc finger."J. Cell Biol. 197:179-187(2012) [PubMed] [Europe PMC] [Abstract]
  18. "Interaction proteomics identify NEURL4 and the HECT E3 ligase HERC2 as novel modulators of centrosome architecture."Mol. Cell. Proteomics 11:M111.014233.01-M111.014233.14(2012) [PubMed] [Europe PMC] [Abstract]
  19. "Structure of the first RCC1-like domain of HERC2."Submitted (JUN-2013) to the PDB data bank
  20. "A homozygous missense mutation in HERC2 associated with global developmental delay and autism spectrum disorder."Hum. Mutat. 33:1639-1646(2012) [PubMed] [Europe PMC] [Abstract]