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HECT Domain And RCC1 Like Domain Protein 1 (HERC1)

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p532; p619; Hect(Homologous To The E6-AP(UBE3A)Carboxyl Terminus)Domain And RCC1(CHC1)-Like Domain(RLD)1; Probable E3 ubiquitin-protein ligase HERC1

HECT Domain And RCC1 Like Domain Protein 1 (HERC1)
CCC L077
HGNC 4867
MGI 2384589
PubMed 12650930
RGD 1306366
UniProt Q15751
Wiki HERC1
The HERC1 protein contains both an N-terminal and a C-terminal RCC1-like domain (RLD), 7 WD domains characteristic of the beta subunit of heterotrimeric G proteins thought to be involved in protein-protein interactions, 3 putative SH3 binding sites, 7 polar amino acid regions, a putative leucine zipper, and a C-terminal HECT domain. Northern blot analysis detected a 15-kb HERC1 transcript expressed ubiquitously in all human and mouse tissues examined, with the highest levels in testis and brain and the lowest in liver.
HERC1 was overexpressed in all human tumor cell lines tested, independent of their developmental origin. Subcellular localization studies indicated that HERC1 is located in the cytosol and the Golgi apparatus.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant HECT Domain And RCC1 Like Domain Protein 1 (HERC1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to HECT Domain And RCC1 Like Domain Protein 1 (HERC1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to HECT Domain And RCC1 Like Domain Protein 1 (HERC1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for HECT Domain And RCC1 Like Domain Protein 1 (HERC1) CLIA Kit Customized Service Offer
n/a ELISA Kit for HECT Domain And RCC1 Like Domain Protein 1 (HERC1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant HECT Domain And RCC1 Like Domain Protein 1 (HERC1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to HECT Domain And RCC1 Like Domain Protein 1 (HERC1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to HECT Domain And RCC1 Like Domain Protein 1 (HERC1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for HECT Domain And RCC1 Like Domain Protein 1 (HERC1) CLIA Kit Customized Service Offer
n/a ELISA Kit for HECT Domain And RCC1 Like Domain Protein 1 (HERC1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant HECT Domain And RCC1 Like Domain Protein 1 (HERC1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to HECT Domain And RCC1 Like Domain Protein 1 (HERC1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to HECT Domain And RCC1 Like Domain Protein 1 (HERC1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for HECT Domain And RCC1 Like Domain Protein 1 (HERC1) CLIA Kit Customized Service Offer
n/a ELISA Kit for HECT Domain And RCC1 Like Domain Protein 1 (HERC1) ELISA Kit Customized Service Offer
  1. "p619, a giant protein related to the chromosome condensation regulator RCC1, stimulates guanine nucleotide exchange on ARF1 and Rab proteins."EMBO J. 15:4262-4273(1996) [PubMed] [Europe PMC] [Abstract]
  2. ErratumEMBO J. 15:5738-5738(1996)
  3. "Analysis of the DNA sequence and duplication history of human chromosome 15." Nature 440:671-675(2006) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "A giant protein that stimulates guanine nucleotide exchange on ARF1 and Rab proteins forms a cytosolic ternary complex with clathrin and Hsp70."Oncogene 15:1-6(1997) [PubMed] [Europe PMC] [Abstract]
  6. "Interaction between HERC1 and M2-type pyruvate kinase."FEBS Lett. 539:78-84(2003) [PubMed] [Europe PMC] [Abstract]
  7. "The giant protein HERC1 is recruited to aluminum fluoride-induced actin-rich surface protrusions in HeLa cells."FEBS Lett. 559:77-83(2004) [PubMed] [Europe PMC] [Abstract]
  8. "Requirement of phosphatidylinositol-4,5-bisphosphate for HERC1-mediated guanine nucleotide release from ARF proteins."FEBS Lett. 579:343-348(2005) [PubMed] [Europe PMC] [Abstract]
  9. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  10. "TSC1 stabilizes TSC2 by inhibiting the interaction between TSC2 and the HERC1 ubiquitin ligase."J. Biol. Chem. 281:8313-8316(2006) [PubMed] [Europe PMC] [Abstract]
  11. "ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage."Science 316:1160-1166(2007) [PubMed] [Europe PMC] [Abstract]
  12. "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
  13. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  14. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  15. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  16. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  17. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  18. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]