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HECT UBA And WWE Domain Containing Protein 1 (HUWE1)

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ARF-BP1; HECTH9; LASU1; MULE; UREB1; ARF-binding protein 1; Homologous to E6AP carboxyl terminus homologous protein 9; Upstream regulatory element-binding protein 1

HECT UBA And WWE Domain Containing Protein 1 (HUWE1)
CCC L076
HGNC 30892
MGI 1926884
PubMed 23721686
UniProt Q7Z6Z7
Wiki HUWE1
HUWE1 encodes a member of the HECT E3 ubiquitin ligase family. The HECT domain lies in the C-terminus and contains the active-site cysteine which forms an intermediate ubiquitin-thioester bond. E3 family members are divided into three subfamilies based on their protein-protein interaction domains; this gene encodes a member of the SI(ngle)-HECT E3 subfamily. In lung, breast, and colorectal carcinomas, this gene is highly expressed. Mutations in this gene has been found in 3 unrelated families with X-linked syndromic mental retardation, Turner type.
Weakly expressed in heart, brain and placenta but not in other tissues. Expressed in a number of cell lines, predominantly in those from colorectal carcinomas.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant HECT UBA And WWE Domain Containing Protein 1 (HUWE1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to HECT UBA And WWE Domain Containing Protein 1 (HUWE1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to HECT UBA And WWE Domain Containing Protein 1 (HUWE1) Polyclonal Antibody Customized Service Offer
Assay Kits SEL076Hu ELISA Kit for HECT UBA And WWE Domain Containing Protein 1 (HUWE1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant HECT UBA And WWE Domain Containing Protein 1 (HUWE1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to HECT UBA And WWE Domain Containing Protein 1 (HUWE1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to HECT UBA And WWE Domain Containing Protein 1 (HUWE1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for HECT UBA And WWE Domain Containing Protein 1 (HUWE1) CLIA Kit Customized Service Offer
n/a ELISA Kit for HECT UBA And WWE Domain Containing Protein 1 (HUWE1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant HECT UBA And WWE Domain Containing Protein 1 (HUWE1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to HECT UBA And WWE Domain Containing Protein 1 (HUWE1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to HECT UBA And WWE Domain Containing Protein 1 (HUWE1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for HECT UBA And WWE Domain Containing Protein 1 (HUWE1) CLIA Kit Customized Service Offer
n/a ELISA Kit for HECT UBA And WWE Domain Containing Protein 1 (HUWE1) ELISA Kit Customized Service Offer
  1. "ARF-BP1/Mule is a critical mediator of the ARF tumor suppressor."Cell 121:1071-1083(2005) [PubMed] [Europe PMC] [Abstract]
  2. "Mule/ARF-BP1, a BH3-only E3 ubiquitin ligase, catalyzes the polyubiquitination of Mcl-1 and regulates apoptosis."Cell 121:1085-1095(2005) [PubMed] [Europe PMC] [Abstract]
  3. "Characterization of E3Histone, a novel testis ubiquitin protein ligase which ubiquitinates histones."Mol. Cell. Biol. 25:2819-2831(2005) [PubMed] [Europe PMC] [Abstract]
  4. "The DNA sequence of the human X chromosome." Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
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  6. "Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."DNA Res. 7:273-281(2000) [PubMed] [Europe PMC] [Abstract]
  7. "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells." Genome Res. 10:1546-1560(2000) [PubMed] [Europe PMC] [Abstract]
  8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  9. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  10. "Over-expression of human UREB1 in colorectal cancer: HECT domain of human UREB1 inhibits the activity of tumor suppressor p53 protein."Biochem. Biophys. Res. Commun. 326:7-17(2005) [PubMed] [Europe PMC] [Abstract]
  11. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  12. "A probability-based approach for high-throughput protein phosphorylation analysis and site localization."Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]
  13. "Cdc6 stability is regulated by the Huwe1 ubiquitin ligase after DNA damage."Mol. Biol. Cell 18:3340-3350(2007) [PubMed] [Europe PMC] [Abstract]
  14. "ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage."Science 316:1160-1166(2007) [PubMed] [Europe PMC] [Abstract]
  15. "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
  16. "Phosphoproteome of resting human platelets."J. Proteome Res. 7:526-534(2008) [PubMed] [Europe PMC] [Abstract]
  17. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
  18. "The HECT-domain ubiquitin ligase Huwe1 controls neural differentiation and proliferation by destabilizing the N-Myc oncoprotein."Nat. Cell Biol. 10:643-653(2008) [PubMed] [Europe PMC] [Abstract]
  19. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  20. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  21. "Ubiquitin ligase ARF-BP1/Mule modulates base excision repair."EMBO J. 28:3207-3215(2009) [PubMed] [Europe PMC] [Abstract]
  22. "Human BRE1 is an E3 ubiquitin ligase for Ebp1 tumor suppressor."Mol. Biol. Cell 20:757-768(2009) [PubMed] [Europe PMC] [Abstract]
  23. "Large-scale proteomics analysis of the human kinome."Mol. Cell. Proteomics 8:1751-1764(2009) [PubMed] [Europe PMC] [Abstract]
  24. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  25. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  26. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  27. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  28. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  29. "Solution structure of RSGI RUH-074, a human UBA domain."Submitted (FEB-2009) to the PDB data bank
  30. "Hect domain of human huwe1/mule."Submitted (MAY-2009) to the PDB data bank
  31. "Submicroscopic duplications of the hydroxysteroid dehydrogenase HSD17B10 and the E3 ubiquitin ligase HUWE1 are associated with mental retardation." Am. J. Hum. Genet. 82:432-443(2008) [PubMed] [Europe PMC] [Abstract]