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Ubiquitin Protein Ligase E3 Component N-Recognin 5 (UBR5)

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DD5; EDD; HYD; EDD1; E3 Ubiquitin Protein Ligase,HECT Domain Containing 1; Hyperplastic discs protein homolog; Progestin-induced protein; E3 ubiquitin-protein ligase UBR5

Ubiquitin Protein Ligase E3 Component N-Recognin 5 (UBR5)
CCC L075
HGNC 16806
MGI 1918040
PubMed 23878065
UniProt O95071
Wiki UBR5
UBR5 encodes a progestin-induced protein, which belongs to the HECT family. The HECT family proteins function as E3 ubiquitin-protein ligases, targeting specific proteins for ubiquitin-mediated proteolysis. This gene is localized to chromosome 8q22 which is disrupted in a variety of cancers. This gene potentially has a role in regulation of cell proliferation or differentiation.The deduced 2,799-amino acid protein contains 2 putative nuclear localization signals, a region sharing homology with polyadenylate-binding proteins, and a C-terminal HECT domain, which contains a conserved cysteine that binds ubiquitin via a thioester linkage. Northern blot analysis detected a 9.5-kb transcript in all tissues examined. RNA dot blot analysis found highest expression in testis, followed by brain, pituitary, and kidney.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Ubiquitin Protein Ligase E3 Component N-Recognin 5 (UBR5) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Ubiquitin Protein Ligase E3 Component N-Recognin 5 (UBR5) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ubiquitin Protein Ligase E3 Component N-Recognin 5 (UBR5) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Ubiquitin Protein Ligase E3 Component N-Recognin 5 (UBR5) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ubiquitin Protein Ligase E3 Component N-Recognin 5 (UBR5) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Ubiquitin Protein Ligase E3 Component N-Recognin 5 (UBR5) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Ubiquitin Protein Ligase E3 Component N-Recognin 5 (UBR5) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ubiquitin Protein Ligase E3 Component N-Recognin 5 (UBR5) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Ubiquitin Protein Ligase E3 Component N-Recognin 5 (UBR5) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ubiquitin Protein Ligase E3 Component N-Recognin 5 (UBR5) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Ubiquitin Protein Ligase E3 Component N-Recognin 5 (UBR5) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Ubiquitin Protein Ligase E3 Component N-Recognin 5 (UBR5) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ubiquitin Protein Ligase E3 Component N-Recognin 5 (UBR5) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Ubiquitin Protein Ligase E3 Component N-Recognin 5 (UBR5) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ubiquitin Protein Ligase E3 Component N-Recognin 5 (UBR5) ELISA Kit Customized Service Offer
  1. "Identification of a human HECT family protein with homology to the Drosophila tumor suppressor gene hyperplastic discs."Oncogene 17:3479-3491(1998) [PubMed] [Europe PMC] [Abstract]
  2. "Cooperation of HECT-domain ubiquitin ligase hHYD and DNA topoisomerase II-binding protein for DNA damage response."J. Biol. Chem. 277:3599-3605(2002) [PubMed] [Europe PMC] [Abstract]
  3. "Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."DNA Res. 5:355-364(1998) [PubMed] [Europe PMC] [Abstract]
  4. "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract]
  5. "DNA sequence and analysis of human chromosome 8." Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells."Nat. Biotechnol. 23:94-101(2005) [PubMed] [Europe PMC] [Abstract]
  8. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  9. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
  10. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  11. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  12. "Large-scale proteomics analysis of the human kinome."Mol. Cell. Proteomics 8:1751-1764(2009) [PubMed] [Europe PMC] [Abstract]
  13. "Protein kinase DYRK2 is a scaffold that facilitates assembly of an E3 ligase."Nat. Cell Biol. 11:409-419(2009) [PubMed] [Europe PMC] [Abstract]
  14. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  15. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  16. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  17. "Transcription factor IIS cooperates with the E3 ligase UBR5 to ubiquitinate the CDK9 subunit of the positive transcription elongation factor B."J. Biol. Chem. 286:5012-5022(2011) [PubMed] [Europe PMC] [Abstract]
  18. "Identification of phosphorylation sites on the E3 ubiquitin ligase UBR5/EDD."J. Proteomics 75:603-609(2011) [PubMed] [Europe PMC] [Abstract]
  19. "Acetylation regulates gluconeogenesis by promoting PEPCK1 degradation via recruiting the UBR5 ubiquitin ligase."Mol. Cell 43:33-44(2011) [PubMed] [Europe PMC] [Abstract]
  20. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  21. "TRIP12 and UBR5 Suppress Spreading of Chromatin Ubiquitylation at Damaged Chromosomes."Cell 150:697-709(2012) [PubMed] [Europe PMC] [Abstract]
  22. "Phosphorylation-dependent PIH1D1 interactions define substrate specificity of the R2TP cochaperone complex."Cell Rep. 7:19-26(2014) [PubMed] [Europe PMC] [Abstract]
  23. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  24. "X-ray structure of the human hyperplastic discs protein: an ortholog of the C-terminal domain of poly(A)-binding protein."Proc. Natl. Acad. Sci. U.S.A. 98:4414-4419(2001) [PubMed] [Europe PMC] [Abstract]