≡

GRB10 Interacting GYF Protein 2 (GIGYF2)

[Edit]

TNRC15; PERQ2; PARK11; GYF2; Trinucleotide Repeat Containing 15; PERQ Amino Acid Rich,With GYF Domain 2; Parkinson Disease(Autosomal Recessive,Early Onset)11

GRB10 Interacting GYF Protein 2 (GIGYF2)
CCC L056
HGNC 11960
MGI 2138584
PubMed 18358451
UniProt Q6Y7W6
Wiki TNRC15
GIGYF2 interacts with GRB10 and may be involved in the regulation of tyrosine kinase receptor signaling. This gene contains CAG repeats, and the encoded protein contains stretches glutamine and glutamic acid residues. Defects in this gene are a cause of Parkinson disease type 11 (PARK11). Multiple transcript variants encoding several different isoforms have been found for this gene.
The deduced 1,292-amino acid protein contains a GYF domain in its N-terminal half and a clathrin light chain homology domain in its C-terminal half. It also has a proline-rich region, multiple Q/E stretches, a consensus bipartite nuclear localization signal, several phosphorylation sites, and binding sites for protein phosphatase-1, 14-3-3 proteins, and phospholipase C-gamma.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant GRB10 Interacting GYF Protein 2 (GIGYF2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to GRB10 Interacting GYF Protein 2 (GIGYF2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to GRB10 Interacting GYF Protein 2 (GIGYF2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for GRB10 Interacting GYF Protein 2 (GIGYF2) CLIA Kit Customized Service Offer
n/a ELISA Kit for GRB10 Interacting GYF Protein 2 (GIGYF2) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant GRB10 Interacting GYF Protein 2 (GIGYF2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to GRB10 Interacting GYF Protein 2 (GIGYF2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to GRB10 Interacting GYF Protein 2 (GIGYF2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for GRB10 Interacting GYF Protein 2 (GIGYF2) CLIA Kit Customized Service Offer
n/a ELISA Kit for GRB10 Interacting GYF Protein 2 (GIGYF2) ELISA Kit Customized Service Offer
  1. "Two novel proteins that are linked to insulin-like growth factor (IGF-I) receptors by the Grb10 adapter and modulate IGF-I signaling."J. Biol. Chem. 278:31564-31573(2003) [PubMed] [Europe PMC] [Abstract]
  2. "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro."DNA Res. 5:169-176(1998) [PubMed] [Europe PMC] [Abstract]
  3. "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract]
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  6. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  8. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  9. "A probability-based approach for high-throughput protein phosphorylation analysis and site localization."Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]
  10. "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
  11. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
  12. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  13. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  14. "Large-scale proteomics analysis of the human kinome."Mol. Cell. Proteomics 8:1751-1764(2009) [PubMed] [Europe PMC] [Abstract]
  15. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  16. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  17. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  18. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  19. "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
  20. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  21. "Mutations in the GIGYF2 (TNRC15) gene at the PARK11 locus in familial Parkinson disease."Am. J. Hum. Genet. 82:822-833(2008) [PubMed] [Europe PMC] [Abstract]