≡

Potassium Voltage Gated Channel KQT Like Subfamily, Member 3 (KCNQ3)

[Edit]

BFNC2; EBN2; KV7.3; KQT-like 3; Potassium channel subunit alpha KvLQT3K; Voltage-gated potassium channel subunit Kv7.3

Potassium Voltage Gated Channel KQT Like Subfamily, Member 3 (KCNQ3)
CCC L053
HGNC 6297
MGI 1336181
PubMed 24375629
RGD 69222
UniProt O43525
Wiki KCNQ3
7.3 (KvLQT3) is a potassium channel protein coded for by the gene KCNQ3.It is associated with benign familial neonatal convulsions.
The M channel is a slowly activating and deactivating potassium channel that plays a critical role in the regulation of neuronal excitability. The M channel is formed by the association of the protein encoded by this gene and one of two related proteins encoded by the KCNQ2 and KCNQ5 genes, both integral membrane proteins. M channel currents are inhibited by M1 muscarinic acetylcholine receptors and activated by retigabine, a novel anti-convulsant drug. Defects in this gene are a cause of benign familial neonatal convulsions type 2 (BFNC2), also known as epilepsy, benign neonatal type 2 (EBN2).

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Potassium Voltage Gated Channel KQT Like Subfamily, Member 3 (KCNQ3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Potassium Voltage Gated Channel KQT Like Subfamily, Member 3 (KCNQ3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Potassium Voltage Gated Channel KQT Like Subfamily, Member 3 (KCNQ3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Potassium Voltage Gated Channel KQT Like Subfamily, Member 3 (KCNQ3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Potassium Voltage Gated Channel KQT Like Subfamily, Member 3 (KCNQ3) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Potassium Voltage Gated Channel KQT Like Subfamily, Member 3 (KCNQ3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Potassium Voltage Gated Channel KQT Like Subfamily, Member 3 (KCNQ3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Potassium Voltage Gated Channel KQT Like Subfamily, Member 3 (KCNQ3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Potassium Voltage Gated Channel KQT Like Subfamily, Member 3 (KCNQ3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Potassium Voltage Gated Channel KQT Like Subfamily, Member 3 (KCNQ3) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Potassium Voltage Gated Channel KQT Like Subfamily, Member 3 (KCNQ3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Potassium Voltage Gated Channel KQT Like Subfamily, Member 3 (KCNQ3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Potassium Voltage Gated Channel KQT Like Subfamily, Member 3 (KCNQ3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Potassium Voltage Gated Channel KQT Like Subfamily, Member 3 (KCNQ3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Potassium Voltage Gated Channel KQT Like Subfamily, Member 3 (KCNQ3) ELISA Kit Customized Service Offer
  1. "Moderate loss of function of cyclic-AMP-modulated KCNQ2/KCNQ3 K+ channels causes epilepsy."Nature 396:687-690(1998) [PubMed] [Europe PMC] [Abstract]
  2. "Functional expression of two KvLQT1-related potassium channels responsible for an inherited idiopathic epilepsy."J. Biol. Chem. 273:19419-19423(1998) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "DNA sequence and analysis of human chromosome 8." Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "A pore mutation in a novel KQT-like potassium channel gene in an idiopathic epilepsy family."Nat. Genet. 18:53-55(1998) [PubMed] [Europe PMC] [Abstract]
  7. "Two types of K(+) channel subunit, Erg1 and KCNQ2/3, contribute to the M-like current in a mammalian neuronal cell."J. Neurosci. 19:7742-7756(1999) [PubMed] [Europe PMC] [Abstract]
  8. "M-type KCNQ2-KCNQ3 potassium channels are modulated by the KCNE2 subunit."FEBS Lett. 480:137-141(2000) [PubMed] [Europe PMC] [Abstract]
  9. "Surface expression and single channel properties of KCNQ2/KCNQ3, M-type K+ channels involved in epilepsy."J. Biol. Chem. 275:13343-13348(2000) [PubMed] [Europe PMC] [Abstract]
  10. "Reconstitution of muscarinic modulation of the KCNQ2/KCNQ3 K(+) channels that underlie the neuronal M current."J. Neurosci. 20:1710-1721(2000) [PubMed] [Europe PMC] [Abstract]
  11. "Inhibition of KCNQ1-4 potassium channels expressed in mammalian cells via M1 muscarinic acetylcholine receptors."J. Physiol. (Lond.) 522:349-355(2000) [PubMed] [Europe PMC] [Abstract]
  12. "Modulation of KCNQ2/3 potassium channels by the novel anticonvulsant retigabine."Mol. Pharmacol. 58:253-262(2000) [PubMed] [Europe PMC] [Abstract]
  13. "Retigabine, a novel anti-convulsant, enhances activation of KCNQ2/Q3 potassium channels."Mol. Pharmacol. 58:591-600(2000) [PubMed] [Europe PMC] [Abstract]
  14. "The novel anticonvulsant retigabine activates M-currents in Chinese hamster ovary-cells transfected with human KCNQ2/3 subunits."Neurosci. Lett. 282:73-76(2000) [PubMed] [Europe PMC] [Abstract]
  15. "Characterization of KCNQ5/Q3 potassium channels expressed in mammalian cells."Br. J. Pharmacol. 132:381-384(2001) [PubMed] [Europe PMC] [Abstract]
  16. "Identification by mass spectrometry and functional characterization of two phosphorylation sites of KCNQ2/KCNQ3 channels."Proc. Natl. Acad. Sci. U.S.A. 102:17828-17833(2005) [PubMed] [Europe PMC] [Abstract]
  17. "A novel mutation of KCNQ3 (c.925T-->C) in a Japanese family with benign familial neonatal convulsions."Ann. Neurol. 47:822-826(2000) [PubMed] [Europe PMC] [Abstract]
  18. "KCNQ2 and KCNQ3 potassium channel genes in benign familial neonatal convulsions: expansion of the functional and mutation spectrum."Brain 126:2726-2737(2003) [PubMed] [Europe PMC] [Abstract]
  19. "Targeted next generation sequencing as a diagnostic tool in epileptic disorders." Epilepsia 53:1387-1398(2012) [PubMed] [Europe PMC] [Abstract]