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Potassium Large Conductance Calcium Activated Channel Subfamily M Beta 1 (KCNMb1)

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SLO-BETA; hslo-beta; BK channel subunit beta-1; Calcium-activated potassium channel subunit beta-1; Charybdotoxin receptor subunit beta-1; Maxi K channel subunit beta-1

Potassium Large Conductance Calcium Activated Channel Subfamily M Beta 1 (KCNMb1)
CCC L048
HGNC 6285
MGI 1334203
PubMed 18418400
RGD 2961
UniProt Q16558
Wiki KCNMB1
SLO-beta, is widely expressed as a 1.4-kb transcript throughout human tissues. Coexpression of the SLO-alpha and -beta subunits in Xenopus oocytes or mammalian cells gave rise to calcium-activated potassium currents with a pronounced increase in calcium and/or voltage sensitivity. the concentration of intracellular calcium controls the functional coupling between beta and alpha subunits of the MaxiK channel complex, switching the alpha subunit from a calcium-independent to a calcium-dependent mode and from a beta subunit dull interaction to a beta subunit-activated mode. The functional switch develops at concentrations of calcium that occur during cellular excitation, providing the molecular basis for how MaxiK channels regulate smooth muscle excitability and neurotransmitter release.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Potassium Large Conductance Calcium Activated Channel Subfamily M Beta 1 (KCNMb1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Potassium Large Conductance Calcium Activated Channel Subfamily M Beta 1 (KCNMb1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Potassium Large Conductance Calcium Activated Channel Subfamily M Beta 1 (KCNMb1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Potassium Large Conductance Calcium Activated Channel Subfamily M Beta 1 (KCNMb1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Potassium Large Conductance Calcium Activated Channel Subfamily M Beta 1 (KCNMb1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Potassium Large Conductance Calcium Activated Channel Subfamily M Beta 1 (KCNMb1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Potassium Large Conductance Calcium Activated Channel Subfamily M Beta 1 (KCNMb1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Potassium Large Conductance Calcium Activated Channel Subfamily M Beta 1 (KCNMb1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Potassium Large Conductance Calcium Activated Channel Subfamily M Beta 1 (KCNMb1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Potassium Large Conductance Calcium Activated Channel Subfamily M Beta 1 (KCNMb1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Potassium Large Conductance Calcium Activated Channel Subfamily M Beta 1 (KCNMb1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Potassium Large Conductance Calcium Activated Channel Subfamily M Beta 1 (KCNMb1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Potassium Large Conductance Calcium Activated Channel Subfamily M Beta 1 (KCNMb1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Potassium Large Conductance Calcium Activated Channel Subfamily M Beta 1 (KCNMb1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Potassium Large Conductance Calcium Activated Channel Subfamily M Beta 1 (KCNMb1) ELISA Kit Customized Service Offer
  1. "A calcium switch for the functional coupling between alpha (hslo) and beta subunits (KV,Ca beta) of maxi K channels."FEBS Lett. 382:84-88(1996) [PubMed] [Europe PMC] [Abstract]
  2. "Phenotypic alteration of a human BK (hSlo) channel by hSlobeta subunit coexpression: changes in blocker sensitivity, activation/relaxation and inactivation kinetics, and protein kinase A modulation."J. Neurosci. 16:4543-4550(1996) [PubMed] [Europe PMC] [Abstract]
  3. "Cloning, expression, and distribution of a Ca(2+)-activated K+ channel beta-subunit from human brain."Proc. Natl. Acad. Sci. U.S.A. 93:9200-9205(1996) [PubMed] [Europe PMC] [Abstract]
  4. "Identification of potassium channels in human lens epithelium."(In) Civan M.M. (eds.);The eye's aqueous humor, from secretion to glaucoma, pp.69-104, Academic Press, San Diego (1998)
  5. "Calcium-activated potassium channel expression in human myometrium: effect of pregnancy."Proc. West. Pharmacol. Soc. 45:184-186(2002) [PubMed] [Europe PMC] [Abstract]
  6. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  8. "A neuronal beta subunit (KCNMB4) makes the large conductance, voltage- and Ca2+-activated K+ channel resistant to charybdotoxin and iberiotoxin."Proc. Natl. Acad. Sci. U.S.A. 97:5562-5567(2000) [PubMed] [Europe PMC] [Abstract]
  9. "Acute activation of Maxi-K channels (hSlo) by estradiol binding to the beta subunit."Science 285:1929-1931(1999) [PubMed] [Europe PMC] [Abstract]
  10. "New disguises for an old channel: MaxiK channel beta-subunits."News Physiol. Sci. 17:156-161(2002) [PubMed] [Europe PMC] [Abstract]
  11. "Gain-of-function mutation in the KCNMB1 potassium channel subunit is associated with low prevalence of diastolic hypertension."J. Clin. Invest. 113:1032-1039(2004) [PubMed] [Europe PMC] [Abstract]