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Potassium Inwardly Rectifying Channel Subfamily J, Member 1 (KCNJ1)

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ROMK1; ROMK; ATP-regulated potassium channel ROM-K; Inward rectifier K(+) channel Kir1.1; ATP-sensitive inward rectifier potassium channel 1

Potassium Inwardly Rectifying Channel Subfamily J, Member 1 (KCNJ1)
CCC L044
HGNC 6255
MGI 1927248
PubMed 22907731
RGD 2957
UniProt P48048
Wiki ROMK
ROMK is an acronym for the Renal Outer Medullary Potassium channel. This is an ATP-dependent potassium channel (Kir1.1) that transports potassium out of cells. It plays an important role in potassium recycling in the thick ascending limb (TAL) and potassium secretion in the cortical collecting duct (CCD) of the nephron.
Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. It is activated by internal ATP and probably plays an important role in potassium homeostasis. The encoded protein has a greater tendency to allow potassium to flow into a cell rather than out of a cell.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Potassium Inwardly Rectifying Channel Subfamily J, Member 1 (KCNJ1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Potassium Inwardly Rectifying Channel Subfamily J, Member 1 (KCNJ1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Potassium Inwardly Rectifying Channel Subfamily J, Member 1 (KCNJ1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Potassium Inwardly Rectifying Channel Subfamily J, Member 1 (KCNJ1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Potassium Inwardly Rectifying Channel Subfamily J, Member 1 (KCNJ1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Potassium Inwardly Rectifying Channel Subfamily J, Member 1 (KCNJ1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Potassium Inwardly Rectifying Channel Subfamily J, Member 1 (KCNJ1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Potassium Inwardly Rectifying Channel Subfamily J, Member 1 (KCNJ1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Potassium Inwardly Rectifying Channel Subfamily J, Member 1 (KCNJ1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Potassium Inwardly Rectifying Channel Subfamily J, Member 1 (KCNJ1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Potassium Inwardly Rectifying Channel Subfamily J, Member 1 (KCNJ1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Potassium Inwardly Rectifying Channel Subfamily J, Member 1 (KCNJ1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Potassium Inwardly Rectifying Channel Subfamily J, Member 1 (KCNJ1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Potassium Inwardly Rectifying Channel Subfamily J, Member 1 (KCNJ1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Potassium Inwardly Rectifying Channel Subfamily J, Member 1 (KCNJ1) ELISA Kit Customized Service Offer
  1. "Cloning and characterization of multiple forms of the human kidney ROM-K potassium channel."J. Biol. Chem. 269:24261-24270(1994) [PubMed] [Europe PMC] [Abstract]
  2. "Alternative splicing of human inwardly rectifying K+ channel ROMK1 mRNA."Mol. Pharmacol. 45:854-860(1994) [PubMed] [Europe PMC] [Abstract]
  3. "Nucleotide sequence analysis of the human KCNJ1 potassium channel locus."Gene 188:9-16(1997) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Isolation and chromosomal localization of a human ATP-regulated potassium channel."Hum. Genet. 96:155-160(1995) [PubMed] [Europe PMC] [Abstract]
  6. "Glycosylation of GIRK1 at Asn119 and ROMK1 at Asn117 has different consequences in potassium channel function."J. Biol. Chem. 275:30677-30682(2000) [PubMed] [Europe PMC] [Abstract]
  7. "Molecular requirements for the regulation of the renal outer medullary K(+) channel ROMK1 by the serum- and glucocorticoid-inducible kinase SGK1."Biochem. Biophys. Res. Commun. 311:629-634(2003) [PubMed] [Europe PMC] [Abstract]
  8. "Cell surface expression of the ROMK (Kir 1.1) channel is regulated by the aldosterone-induced kinase, SGK-1, and protein kinase A."J. Biol. Chem. 278:23066-23075(2003) [PubMed] [Europe PMC] [Abstract]
  9. "WNK3, a kinase related to genes mutated in hereditary hypertension with hyperkalaemia, regulates the K+ channel ROMK1 (Kir1.1)."J. Physiol. (Lond.) 571:275-286(2006) [PubMed] [Europe PMC] [Abstract]
  10. "Genetic heterogeneity of Bartter's syndrome revealed by mutations in the K+ channel, ROMK."Nat. Genet. 14:152-156(1996) [PubMed] [Europe PMC] [Abstract]
  11. "Mutations in the gene encoding the inwardly-rectifying renal potassium channel, ROMK, cause the antenatal variant of Bartter syndrome: evidence for genetic heterogeneity." Hum. Mol. Genet. 6:17-26(1997) [PubMed] [Europe PMC] [Abstract]
  12. "A hyperprostaglandin E syndrome mutation in Kir1.1 (renal outer medullary potassium) channels reveals a crucial residue for channel function in Kir1.3 channels."J. Biol. Chem. 273:23884-23891(1998) [PubMed] [Europe PMC] [Abstract]
  13. "The consensus coding sequences of human breast and colorectal cancers." Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]