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Potassium Voltage Gated Channel Isk Related Family, Member 1 (KCNE1)

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ISK; JLNS; LQT5; MinK; Delayed rectifier potassium channel subunit IsK; IKs producing slow voltage-gated potassium channel subunit beta Mink; Minimal potassium channel

Potassium Voltage Gated Channel Isk Related Family, Member 1 (KCNE1)
CCC L034
HGNC 6240
MGI 96673
PubMed 22100668
RGD 2956
UniProt P15382
Wiki KCNE1
KCNE1 encodes a transmembrane protein known to associate with the product of the KVLQT1 gene to form the delayed rectifier potassium channel. Mutation in this gene are associated with both Jervell and Lange-Nielsen and Romano-Ward forms of long-QT syndrome. Alternatively spliced transcript variants encoding the same protein have been identified.
The protein consisted of 129 amino acid residues and shared structural characteristics with the rat counterpart. The transmembrane domain and its flanking C-terminal sequence were highly conserved between the human and rat sequences. The slowly activating potassium current elicited by the human protein on its expression in Xenopus oocytes was indistinguishable from that induced by the rat protein.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Potassium Voltage Gated Channel Isk Related Family, Member 1 (KCNE1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Potassium Voltage Gated Channel Isk Related Family, Member 1 (KCNE1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Potassium Voltage Gated Channel Isk Related Family, Member 1 (KCNE1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Potassium Voltage Gated Channel Isk Related Family, Member 1 (KCNE1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Potassium Voltage Gated Channel Isk Related Family, Member 1 (KCNE1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Potassium Voltage Gated Channel Isk Related Family, Member 1 (KCNE1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Potassium Voltage Gated Channel Isk Related Family, Member 1 (KCNE1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Potassium Voltage Gated Channel Isk Related Family, Member 1 (KCNE1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Potassium Voltage Gated Channel Isk Related Family, Member 1 (KCNE1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Potassium Voltage Gated Channel Isk Related Family, Member 1 (KCNE1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Potassium Voltage Gated Channel Isk Related Family, Member 1 (KCNE1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Potassium Voltage Gated Channel Isk Related Family, Member 1 (KCNE1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Potassium Voltage Gated Channel Isk Related Family, Member 1 (KCNE1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Potassium Voltage Gated Channel Isk Related Family, Member 1 (KCNE1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Potassium Voltage Gated Channel Isk Related Family, Member 1 (KCNE1) ELISA Kit Customized Service Offer
  1. "Molecular cloning and sequence analysis of human genomic DNA encoding a novel membrane protein which exhibits a slowly activating potassium channel activity."Biochem. Biophys. Res. Commun. 161:176-181(1989) [PubMed] [Europe PMC] [Abstract]
  2. "Polymorphism of the gene encoding a human minimal potassium ion channel (minK)."Gene 151:339-340(1994) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Properties of KvLQT1 K+ channel mutations in Romano-Ward and Jervell and Lange-Nielsen inherited cardiac arrhythmias."EMBO J. 16:5472-5479(1997) [PubMed] [Europe PMC] [Abstract]
  5. "A minK-HERG complex regulates the cardiac potassium current I(Kr)."Nature 388:289-292(1997) [PubMed] [Europe PMC] [Abstract]
  6. "Disease-associated mutations in KCNE potassium channel subunits (MiRPs) reveal promiscuous disruption of multiple currents and conservation of mechanism."FASEB J. 16:390-400(2002) [PubMed] [Europe PMC] [Abstract]
  7. "Post-translational N-glycosylation of type I transmembrane KCNE1 peptides: implications for membrane protein biogenesis and disease."J. Biol. Chem. 286:28150-28159(2011) [PubMed] [Europe PMC] [Abstract]
  8. "O-glycosylation of the cardiac I(Ks) complex."J. Physiol. (Lond.) 589:3721-3730(2011) [PubMed] [Europe PMC] [Abstract]
  9. "Structure of KCNE1 and implications for how it modulates the KCNQ1 potassium channel."Biochemistry 47:7999-8006(2008) [PubMed] [Europe PMC] [Abstract]
  10. "Exclusion of KCNE1 (IsK) as a candidate gene for Jervell and Lange-Nielsen syndrome."J. Mol. Cell. Cardiol. 28:2051-2055(1996) [PubMed] [Europe PMC] [Abstract]
  11. "IsK and KvLQT1: mutation in either of the two subunits of the slow component of the delayed rectifier potassium channel can cause Jervell and Lange-Nielsen syndrome."Hum. Mol. Genet. 6:2179-2185(1997) [PubMed] [Europe PMC] [Abstract]
  12. "KCNE1 mutations cause Jervell and Lange-Nielsen syndrome."Nat. Genet. 17:267-268(1997) [PubMed] [Europe PMC] [Abstract]
  13. "Mutations in the hminK gene cause long QT syndrome and suppress IKs function."Nat. Genet. 17:338-340(1997) [PubMed] [Europe PMC] [Abstract]
  14. "Mutation of the gene for IsK associated with both Jervell and Lange-Nielsen and Romano-Ward forms of Long-QT syndrome."Circulation 97:142-146(1998) [PubMed] [Europe PMC] [Abstract]
  15. "Cellular dysfunction of LQT5-minK mutants: abnormalities of IKs, IKr and trafficking in long QT syndrome."Hum. Mol. Genet. 8:1499-1507(1999) [PubMed] [Europe PMC] [Abstract]
  16. "Spectrum of mutations in long-QT syndrome genes. KVLQT1, HERG, SCN5A, KCNE1, and KCNE2."Circulation 102:1178-1185(2000) [PubMed] [Europe PMC] [Abstract]
  17. "A novel long-QT 5 gene mutation in the C-terminus (V109I) is associated with a mild phenotype."J. Mol. Med. 79:504-509(2001) [PubMed] [Europe PMC] [Abstract]
  18. "Compound mutations: a common cause of severe long-QT syndrome."Circulation 109:1834-1841(2004) [PubMed] [Europe PMC] [Abstract]
  19. "The contribution of genes involved in potassium-recycling in the inner ear to noise-induced hearing loss."Hum. Mutat. 27:786-795(2006) [PubMed] [Europe PMC] [Abstract]