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Potassium Voltage Gated Channel Shal Related Subfamily, Member 3 (KCND3)

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KCND3L; KCND3S; KSHIVB; KV4.3; Voltage-gated potassium channel subunit Kv4.3

Potassium Voltage Gated Channel Shal Related Subfamily, Member 3 (KCND3)
CCC L033
HGNC 6239
MGI 1928743
PubMed 23280838
RGD 68394
UniProt Q9UK17
Wiki KCND3
Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume.
4.3 is a member of the potassium channel, voltage-gated, shal-related subfamily, members of which form voltage-activated A-type potassium ion channels and are prominent in the repolarization phase of the action potential. This member includes two isoforms with different sizes, which are encoded by alternatively spliced transcript variants of this gene.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Potassium Voltage Gated Channel Shal Related Subfamily, Member 3 (KCND3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Potassium Voltage Gated Channel Shal Related Subfamily, Member 3 (KCND3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Potassium Voltage Gated Channel Shal Related Subfamily, Member 3 (KCND3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Potassium Voltage Gated Channel Shal Related Subfamily, Member 3 (KCND3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Potassium Voltage Gated Channel Shal Related Subfamily, Member 3 (KCND3) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Potassium Voltage Gated Channel Shal Related Subfamily, Member 3 (KCND3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Potassium Voltage Gated Channel Shal Related Subfamily, Member 3 (KCND3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Potassium Voltage Gated Channel Shal Related Subfamily, Member 3 (KCND3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Potassium Voltage Gated Channel Shal Related Subfamily, Member 3 (KCND3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Potassium Voltage Gated Channel Shal Related Subfamily, Member 3 (KCND3) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Potassium Voltage Gated Channel Shal Related Subfamily, Member 3 (KCND3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Potassium Voltage Gated Channel Shal Related Subfamily, Member 3 (KCND3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Potassium Voltage Gated Channel Shal Related Subfamily, Member 3 (KCND3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Potassium Voltage Gated Channel Shal Related Subfamily, Member 3 (KCND3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Potassium Voltage Gated Channel Shal Related Subfamily, Member 3 (KCND3) ELISA Kit Customized Service Offer
  1. "Isolation and characterization of the human gene encoding Ito: further diversity by alternative mRNA splicing."Am. J. Physiol. 275:H1963-H1970(1998) [PubMed] [Europe PMC] [Abstract]
  2. "Cloning and expression of the human Kv4.3 potassium channel."J. Neurophysiol. 81:1974-1977(1999) [PubMed] [Europe PMC] [Abstract]
  3. "Gene structures and expression profiles of three human KCND (Kv4) potassium channels mediating A-type currents I(TO) and I(SA)."Genomics 64:144-154(2000) [PubMed] [Europe PMC] [Abstract]
  4. "The DNA sequence and biological annotation of human chromosome 1." Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Modulation of Kv4.3 current by accessory subunits."FEBS Lett. 528:183-188(2002) [PubMed] [Europe PMC] [Abstract]
  7. "Kv4 potassium channels form a tripartite complex with the anchoring protein SAP97 and CaMKII in cardiac myocytes."Circ. Res. 104:758-769(2009) [PubMed] [Europe PMC] [Abstract]
  8. "Novel mutations in the KCND3-encoded Kv4.3 K+ channel associated with autopsy-negative sudden unexplained death."Hum. Mutat. 33:989-997(2012) [PubMed] [Europe PMC] [Abstract]
  9. "Two N-terminal domains of Kv4 K(+) channels regulate binding to and modulation by KChIP1." Neuron 41:587-598(2004) [PubMed] [Europe PMC] [Abstract]
  10. "Structural basis for modulation of Kv4 K+ channels by auxiliary KChIP subunits."Nat. Neurosci. 10:32-39(2007) [PubMed] [Europe PMC] [Abstract]
  11. "The consensus coding sequences of human breast and colorectal cancers." Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]
  12. "Mutations in KCND3 cause spinocerebellar ataxia type 22." Ann. Neurol. 72:859-869(2012) [PubMed] [Europe PMC] [Abstract]
  13. "Mutations in potassium channel kcnd3 cause spinocerebellar ataxia type 19."Ann. Neurol. 72:870-880(2012) [PubMed] [Europe PMC] [Abstract]