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Potassium Voltage Gated Channel Shal Related Subfamily, Member 2 (KCND2)

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Kv4.2; RK5; Voltage-gated potassium channel subunit Kv4.2

Potassium Voltage Gated Channel Shal Related Subfamily, Member 2 (KCND2)
CCC L032
HGNC 6238
MGI 102663
PubMed 23734001
RGD 68393
UniProt Q9NZV8
Wiki KCND2
Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume.
KCND2 encodes a member of the potassium channel, voltage-gated, shal-related subfamily, members of which form voltage-activated A-type potassium ion channels and are prominent in the repolarization phase of the action potential. This member mediates a rapidly inactivating, A-type outward potassium current which is not under the control of the N terminus as it is in Shaker channels.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Potassium Voltage Gated Channel Shal Related Subfamily, Member 2 (KCND2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Potassium Voltage Gated Channel Shal Related Subfamily, Member 2 (KCND2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Potassium Voltage Gated Channel Shal Related Subfamily, Member 2 (KCND2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Potassium Voltage Gated Channel Shal Related Subfamily, Member 2 (KCND2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Potassium Voltage Gated Channel Shal Related Subfamily, Member 2 (KCND2) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Potassium Voltage Gated Channel Shal Related Subfamily, Member 2 (KCND2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Potassium Voltage Gated Channel Shal Related Subfamily, Member 2 (KCND2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Potassium Voltage Gated Channel Shal Related Subfamily, Member 2 (KCND2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Potassium Voltage Gated Channel Shal Related Subfamily, Member 2 (KCND2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Potassium Voltage Gated Channel Shal Related Subfamily, Member 2 (KCND2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Potassium Voltage Gated Channel Shal Related Subfamily, Member 2 (KCND2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Potassium Voltage Gated Channel Shal Related Subfamily, Member 2 (KCND2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Potassium Voltage Gated Channel Shal Related Subfamily, Member 2 (KCND2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Potassium Voltage Gated Channel Shal Related Subfamily, Member 2 (KCND2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Potassium Voltage Gated Channel Shal Related Subfamily, Member 2 (KCND2) ELISA Kit Customized Service Offer
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  3. "Characterization of human Kv4.2 mediating a rapidly-inactivating transient voltage-sensitive K+ current."Recept. Channels 6:387-400(1999) [PubMed] [Europe PMC] [Abstract]
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  8. "Modulation of A-type potassium channels by a family of calcium sensors."Nature 403:553-556(2000) [PubMed] [Europe PMC] [Abstract]
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  10. "Kinetic analysis of open- and closed-state inactivation transitions in human Kv4.2 A-type potassium channels."J. Physiol. (Lond.) 535:65-81(2001) [PubMed] [Europe PMC] [Abstract]
  11. "Expression of voltage-gated K+ channels in human atrium."Basic Res. Cardiol. 97:424-433(2002) [PubMed] [Europe PMC] [Abstract]
  12. "Molecular cloning and characterization of CALP/KChIP4, a novel EF-hand protein interacting with presenilin 2 and voltage-gated potassium channel subunit Kv4."J. Biol. Chem. 277:14965-14975(2002) [PubMed] [Europe PMC] [Abstract]
  13. "PKA modulation of Kv4.2-encoded A-type potassium channels requires formation of a supramolecular complex."J. Neurosci. 22:10123-10133(2002) [PubMed] [Europe PMC] [Abstract]
  14. "N-type inactivation features of Kv4.2 channel gating."Biophys. J. 86:210-223(2004) [PubMed] [Europe PMC] [Abstract]
  15. "Modulation of Kv4.2 channel expression and gating by dipeptidyl peptidase 10 (DPP10)."Biophys. J. 87:2380-2396(2004) [PubMed] [Europe PMC] [Abstract]
  16. "Protein-protein interactions of KChIP proteins and Kv4.2."Biochem. Biophys. Res. Commun. 321:606-610(2004) [PubMed] [Europe PMC] [Abstract]
  17. "A Kv4.2 truncation mutation in a patient with temporal lobe epilepsy."Neurobiol. Dis. 24:245-253(2006) [PubMed] [Europe PMC] [Abstract]
  18. "Ionic channel function in action potential generation: current perspective."Mol. Neurobiol. 35:129-150(2007) [PubMed] [Europe PMC] [Abstract]
  19. "The neuronal Kv4 channel complex."Neurochem. Res. 33:1558-1567(2008) [PubMed] [Europe PMC] [Abstract]
  20. "Dynamic coupling of voltage sensor and gate involved in closed-state inactivation of Kv4.2 channels."J. Gen. Physiol. 133:205-224(2009) [PubMed] [Europe PMC] [Abstract]
  21. "The stoichiometry and biophysical properties of the Kv4 potassium channel complex with K+ channel-interacting protein (KChIP) subunits are variable, depending on the relative expression level."J. Biol. Chem. 289:17597-17609(2014) [PubMed] [Europe PMC] [Abstract]
  22. "Three-dimensional structure of I(to); Kv4.2-KChIP2 ion channels by electron microscopy at 21 Angstrom resolution."Neuron 41:513-519(2004) [PubMed] [Europe PMC] [Abstract]
  23. "Ito channels are octameric complexes with four subunits of each Kv4.2 and K+ channel-interacting protein 2."J. Biol. Chem. 279:5549-5554(2004) [PubMed] [Europe PMC] [Abstract]
  24. "Voltage-dependent K+ channel acts as sex steroid sensor in endocrine cells of the human ovary."J. Cell. Physiol. 206:167-174(2006) [PubMed] [Europe PMC] [Abstract]
  25. "Two N-terminal domains of Kv4 K(+) channels regulate binding to and modulation by KChIP1." Neuron 41:587-598(2004) [PubMed] [Europe PMC] [Abstract]
  26. "Kv4 potassium channels form a tripartite complex with the anchoring protein SAP97 and CaMKII in cardiac myocytes."Circ. Res. 104:758-769(2009) [PubMed] [Europe PMC] [Abstract]
  27. "Exome sequencing identifies de novo gain of function missense mutation in KCND2 in identical twins with autism and seizures that slows potassium channel inactivation."Hum. Mol. Genet. 23:3481-3489(2014) [PubMed] [Europe PMC] [Abstract]