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Potassium Voltage Gated Channel Shaw Related Subfamily, Member 4 (KCNC4)

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HKSHIIIC; KSHIIIC; KV3.4; Voltage-gated potassium channel subunit Kv3.4

Potassium Voltage Gated Channel Shaw Related Subfamily, Member 4 (KCNC4)
CCC L030
HGNC 6236
MGI 96670
PubMed 11207363
UniProt Q03721
Wiki KCNC4
The Shaker gene family of Drosophila encodes components of voltage-gated potassium channels and comprises four subfamilies. Based on sequence similarity, this gene is similar to the Shaw subfamily.
KCNC4 belongs to the delayed rectifier class of channel proteins and is an integral membrane protein that mediates the voltage-dependent potassium ion permeability of excitable membranes. It generates atypical voltage-dependent transient current that may be important for neuronal excitability. Several transcript variants encoding different isoforms have been found for this gene.Rudy et al. (1991) reported the cloning of a human K+ channel ShIII cDNA (HKShIIIC) obtained from a brainstem cDNA library. By in situ hybridization, they demonstrated that the gene maps to 1p21.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Potassium Voltage Gated Channel Shaw Related Subfamily, Member 4 (KCNC4) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Potassium Voltage Gated Channel Shaw Related Subfamily, Member 4 (KCNC4) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Potassium Voltage Gated Channel Shaw Related Subfamily, Member 4 (KCNC4) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Potassium Voltage Gated Channel Shaw Related Subfamily, Member 4 (KCNC4) CLIA Kit Customized Service Offer
n/a ELISA Kit for Potassium Voltage Gated Channel Shaw Related Subfamily, Member 4 (KCNC4) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Potassium Voltage Gated Channel Shaw Related Subfamily, Member 4 (KCNC4) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Potassium Voltage Gated Channel Shaw Related Subfamily, Member 4 (KCNC4) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Potassium Voltage Gated Channel Shaw Related Subfamily, Member 4 (KCNC4) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Potassium Voltage Gated Channel Shaw Related Subfamily, Member 4 (KCNC4) CLIA Kit Customized Service Offer
n/a ELISA Kit for Potassium Voltage Gated Channel Shaw Related Subfamily, Member 4 (KCNC4) ELISA Kit Customized Service Offer
  1. "Cloning of ShIII (Shaw-like) cDNAs encoding a novel high-voltage-activating, TEA-sensitive, type-A K+ channel."Proc. R. Soc. B 248:9-18(1992) [PubMed] [Europe PMC] [Abstract]
  2. "The DNA sequence and biological annotation of human chromosome 1." Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Elimination of rapid potassium channel inactivation by phosphorylation of the inactivation gate."Neuron 13:1403-1412(1994) [PubMed] [Europe PMC] [Abstract]
  5. "Interactions between multiple phosphorylation sites in the inactivation particle of a K+ channel. Insights into the molecular mechanism of protein kinase C action."J. Gen. Physiol. 112:71-84(1998) [PubMed] [Europe PMC] [Abstract]
  6. "NMR structure of inactivation gates from mammalian voltage-dependent potassium channels."Nature 385:272-275(1997) [PubMed] [Europe PMC] [Abstract]
  7. "Control of K+ channel gating by protein phosphorylation: structural switches of the inactivation gate."Nat. Struct. Biol. 6:146-150(1999) [PubMed] [Europe PMC] [Abstract]