≡

Transmembrane Protein 70 (TMEM70)

[Edit]

Transmembrane Protein 70 (TMEM70)
CCC K487
HGNC 26050
MGI 1915068
PubMed 20937241
RGD 1566224
UniProt Q9BUB7
TMEM70 likely encodes a mitochondrial membrane protein. The encoded protein may play a role in biogenesis of mitochondrial ATP synthase. Mutations in this gene have been associated with neonatal mitochondrial encephalocardiomyopathy due to ATP synthase deficiency. Alternatively spliced transcript variants have been described.
The deduced protein contains a conserved DUF1301 domain and 2 putative transmembrane regions. RT-PCR detected TMEM70 in all tissues examined, which included liver, muscle, kidney, and pancreas, as well as in fibroblasts. Phylogenetic analysis revealed TMEM70 orthologs in multicellular eukaryotes and plants, but not in yeast and fungi.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Transmembrane Protein 70 (TMEM70) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Transmembrane Protein 70 (TMEM70) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Transmembrane Protein 70 (TMEM70) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Transmembrane Protein 70 (TMEM70) CLIA Kit Customized Service Offer
n/a ELISA Kit for Transmembrane Protein 70 (TMEM70) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Transmembrane Protein 70 (TMEM70) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Transmembrane Protein 70 (TMEM70) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Transmembrane Protein 70 (TMEM70) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Transmembrane Protein 70 (TMEM70) CLIA Kit Customized Service Offer
n/a ELISA Kit for Transmembrane Protein 70 (TMEM70) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Transmembrane Protein 70 (TMEM70) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Transmembrane Protein 70 (TMEM70) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Transmembrane Protein 70 (TMEM70) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Transmembrane Protein 70 (TMEM70) CLIA Kit Customized Service Offer
n/a ELISA Kit for Transmembrane Protein 70 (TMEM70) ELISA Kit Customized Service Offer
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  2. "DNA sequence and analysis of human chromosome 8." Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "TMEM70 mutations cause isolated ATP synthase deficiency and neonatal mitochondrial encephalocardiomyopathy." Nat. Genet. 40:1288-1290(2008) [PubMed] [Europe PMC] [Abstract]
  5. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  6. "Expression and processing of the TMEM70 protein."Biochim. Biophys. Acta 1807:144-149(2011) [PubMed] [Europe PMC] [Abstract]
  7. "TMEM70: a mutational hot spot in nuclear ATP synthase deficiency with a pivotal role in complex V biogenesis."Neurogenetics 13:375-386(2012) [PubMed] [Europe PMC] [Abstract]