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Transmembrane Protein 48 (TMEM48)

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NET3; NDC1; Nucleoporin NDC1

Transmembrane Protein 48 (TMEM48)
CCC K482
HGNC 25525
MGI 1920037
PubMed 19703420
RGD 1560173
UniProt Q9BTX1
Wiki TMEM48
NDC1 has a role in the assembly of nuclear pore complexes and the nuclear envelope in vivo and in vitro. Rat Ndc1 interacted with Nup53 in vitro. NDC1 depletion by RNA interference reduced binding of the Nup53-Nup93 subcomplex to the assembling nuclear pore complex in HeLa cells.
The deduced 611-amino acid protein has 6 transmembrane domains and several putative phosphorylation sites. Immunohistochemical analysis detected NDC1 along the nuclear envelope, where it colocalized with p62 (NUP62) at the nuclear rim. In HeLa cells, the apparent molecular mass of endogenous NDC1 was reduced following phosphatase treatment.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Transmembrane Protein 48 (TMEM48) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Transmembrane Protein 48 (TMEM48) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Transmembrane Protein 48 (TMEM48) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Transmembrane Protein 48 (TMEM48) CLIA Kit Customized Service Offer
n/a ELISA Kit for Transmembrane Protein 48 (TMEM48) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Transmembrane Protein 48 (TMEM48) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Transmembrane Protein 48 (TMEM48) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Transmembrane Protein 48 (TMEM48) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Transmembrane Protein 48 (TMEM48) CLIA Kit Customized Service Offer
n/a ELISA Kit for Transmembrane Protein 48 (TMEM48) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Transmembrane Protein 48 (TMEM48) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Transmembrane Protein 48 (TMEM48) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Transmembrane Protein 48 (TMEM48) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Transmembrane Protein 48 (TMEM48) CLIA Kit Customized Service Offer
n/a ELISA Kit for Transmembrane Protein 48 (TMEM48) ELISA Kit Customized Service Offer
  1. "NDC1: a crucial membrane-integral nucleoporin of metazoan nuclear pore complexes."J. Cell Biol. 173:509-519(2006) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence and biological annotation of human chromosome 1." Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Nuclear membrane proteins with potential disease links found by subtractive proteomics."Science 301:1380-1382(2003) [PubMed] [Europe PMC] [Abstract]
  6. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  7. "The conserved transmembrane nucleoporin NDC1 is required for nuclear pore complex assembly in vertebrate cells."Mol. Cell 22:93-103(2006) [PubMed] [Europe PMC] [Abstract]
  8. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
  9. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  10. "The nuclear pore complex protein ALADIN is anchored via NDC1 but not via POM121 and GP210 in the nuclear envelope."Biochem. Biophys. Res. Commun. 390:205-210(2009) [PubMed] [Europe PMC] [Abstract]
  11. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  12. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]