≡

Transmembrane Protein 30A (TMEM30A)

[Edit]

CDC50A; C6orf67; P4-ATPase flippase complex beta subunit TMEM30A; Cell cycle control protein 50A

Transmembrane Protein 30A (TMEM30A)
CCC K478
HGNC 16667
MGI 106402
PubMed 21289302
RGD 1303315
UniProt Q9NV96
Antitumor alkylphospholipids initiate apoptosis in transformed HL-60 and Jurkat cells while sparing their progenitors. 1-O-Alkyl-2-carboxymethyl-sn-glycero-3-phosphocholine (Edelfosine) like other short-chained phospholipids--inflammatory platelet-activating factor (PAF) and apoptotic oxidatively truncated phospholipids--are proposed to have intracellular sites of action, yet a conduit for these choline phospholipids into mammalian cells is undefined. Edelfosine is also accumulated by Saccharomyces cerevisiae in a process requiring the membrane protein Lem3p, and the human genome contains a Lem3p homolog TMEM30a. Import of choline phospholipids into S. cerevisiae ΔLem3 is partially reconstituted by human TMEM30a and by Lem3p-TMEM30a chimeras, showing the proteins are orthologous.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Transmembrane Protein 30A (TMEM30A) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Transmembrane Protein 30A (TMEM30A) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Transmembrane Protein 30A (TMEM30A) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Transmembrane Protein 30A (TMEM30A) CLIA Kit Customized Service Offer
n/a ELISA Kit for Transmembrane Protein 30A (TMEM30A) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Transmembrane Protein 30A (TMEM30A) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Transmembrane Protein 30A (TMEM30A) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Transmembrane Protein 30A (TMEM30A) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Transmembrane Protein 30A (TMEM30A) CLIA Kit Customized Service Offer
n/a ELISA Kit for Transmembrane Protein 30A (TMEM30A) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Transmembrane Protein 30A (TMEM30A) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Transmembrane Protein 30A (TMEM30A) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Transmembrane Protein 30A (TMEM30A) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Transmembrane Protein 30A (TMEM30A) CLIA Kit Customized Service Offer
n/a ELISA Kit for Transmembrane Protein 30A (TMEM30A) ELISA Kit Customized Service Offer
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  2. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence and analysis of human chromosome 6." Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Identification and characterization of CDC50A, CDC50B and CDC50C genes in silico."Oncol. Rep. 12:939-943(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  7. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
  8. "Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins."Nat. Biotechnol. 27:378-386(2009) [PubMed] [Europe PMC] [Abstract]
  9. "CDC50A plays a key role in the uptake of the anticancer drug perifosine in human carcinoma cells."Biochem. Pharmacol. 80:793-800(2010) [PubMed] [Europe PMC] [Abstract]
  10. "Heteromeric interactions required for abundance and subcellular localization of human CDC50 proteins and class 1 P4-ATPases."J. Biol. Chem. 285:40088-40096(2010) [PubMed] [Europe PMC] [Abstract]
  11. "CDC50 proteins are critical components of the human class-1 P4-ATPase transport machinery."J. Biol. Chem. 285:40562-40572(2010) [PubMed] [Europe PMC] [Abstract]
  12. "Critical role of the beta-subunit CDC50A in the stable expression, assembly, subcellular localization, and lipid transport activity of the P4-ATPase ATP8A2."J. Biol. Chem. 286:17205-17216(2011) [PubMed] [Europe PMC] [Abstract]
  13. "ATP9B, a P4-ATPase (a putative aminophospholipid translocase), localizes to the trans-Golgi network in a CDC50 protein-independent manner."J. Biol. Chem. 286:38159-38167(2011) [PubMed] [Europe PMC] [Abstract]
  14. "Human TMEM30a promotes uptake of antitumor and bioactive choline phospholipids into mammalian cells."J. Immunol. 186:3215-3225(2011) [PubMed] [Europe PMC] [Abstract]