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Sad-1 And Unc-84 Domain Containing Protein 1 (SUN1)

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UNC84A; Unc-84 Homolog A

Sad-1 And Unc-84 Domain Containing Protein 1 (SUN1)
CCC K468
HGNC 18587
MGI 1924303
RGD 1359142
UniProt O94901
The deduced protein contains 310 amino acids. Overall the mouse and human proteins share 75% homology, and they share 89% homology in the C-terminal Sad1/Unc84 (SUN) domain. Northern blot analysis of mouse tissues detected a 4.3-kb transcript in all tissues examined, with highest levels in heart, brain, and testis, and a 2.5-kb transcript only in testis. Northern blot analysis of isolated testicular germ cells detected the 4.3-kb transcript in pachytene spermatocytes and the 2.5-kb transcript primarily in postmeiotic cells. Unc84a transfected into NIH-3T3 mouse fibroblasts showed 2 patterns of distribution. One pattern was predominantly cytoplasmic with perinuclear accumulation, and the other exhibited both nuclear and cytoplasmic staining, but no accumulation in the nucleoli.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Sad-1 And Unc-84 Domain Containing Protein 1 (SUN1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Sad-1 And Unc-84 Domain Containing Protein 1 (SUN1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Sad-1 And Unc-84 Domain Containing Protein 1 (SUN1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Sad-1 And Unc-84 Domain Containing Protein 1 (SUN1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Sad-1 And Unc-84 Domain Containing Protein 1 (SUN1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Sad-1 And Unc-84 Domain Containing Protein 1 (SUN1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Sad-1 And Unc-84 Domain Containing Protein 1 (SUN1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Sad-1 And Unc-84 Domain Containing Protein 1 (SUN1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Sad-1 And Unc-84 Domain Containing Protein 1 (SUN1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Sad-1 And Unc-84 Domain Containing Protein 1 (SUN1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Sad-1 And Unc-84 Domain Containing Protein 1 (SUN1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Sad-1 And Unc-84 Domain Containing Protein 1 (SUN1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Sad-1 And Unc-84 Domain Containing Protein 1 (SUN1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Sad-1 And Unc-84 Domain Containing Protein 1 (SUN1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Sad-1 And Unc-84 Domain Containing Protein 1 (SUN1) ELISA Kit Customized Service Offer
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  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  4. "The DNA sequence of human chromosome 7." Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "UNC-84 localizes to the nuclear envelope and is required for nuclear migration and anchoring during C. elegans development."Development 126:3171-3181(1999) [PubMed] [Europe PMC] [Abstract]
  7. "Nuclear membrane proteins with potential disease links found by subtractive proteomics."Science 301:1380-1382(2003) [PubMed] [Europe PMC] [Abstract]
  8. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  9. "Telomere anchoring at the nuclear periphery requires the budding yeast Sad1-UNC-84 domain protein Mps3."J. Cell Biol. 179:845-854(2007) [PubMed] [Europe PMC] [Abstract]
  10. "Characterization of the structures involved in localization of the SUN proteins to the nuclear envelope and the centrosome."DNA Cell Biol. 25:554-562(2006) [PubMed] [Europe PMC] [Abstract]
  11. "Nuclear envelope localization of human UNC84A does not require nuclear lamins."FEBS Lett. 580:1263-1268(2006) [PubMed] [Europe PMC] [Abstract]
  12. "Histone acetyltransferase hALP and nuclear membrane protein hsSUN1 function in de-condensation of mitotic chromosomes."J. Biol. Chem. 282:27447-27458(2007) [PubMed] [Europe PMC] [Abstract]
  13. "Sun1 forms immobile macromolecular assemblies at the nuclear envelope."Biochim. Biophys. Acta 1783:2415-2426(2008) [PubMed] [Europe PMC] [Abstract]
  14. "Structural requirements for the assembly of LINC complexes and their function in cellular mechanical stiffness."Exp. Cell Res. 314:1892-1905(2008) [PubMed] [Europe PMC] [Abstract]
  15. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  16. "Mammalian SUN protein interaction networks at the inner nuclear membrane and their role in laminopathy disease processes."J. Biol. Chem. 285:3487-3498(2010) [PubMed] [Europe PMC] [Abstract]
  17. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  18. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  19. "Contribution of SUN1 mutations to the pathomechanism in muscular dystrophies."Hum. Mutat. 35:452-461(2014) [PubMed] [Europe PMC] [Abstract]