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WD Repeat And HMG Box DNA Binding Protein 1 (WDHD1)

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AND-1; CTF4; CHTF4; Chromosome Transmission Fidelity Factor 4 Homolog; Acidic nucleoplasmic DNA-binding protein 1

WD Repeat And HMG Box DNA Binding Protein 1 (WDHD1)
CCC K466
HGNC 23170
MGI 2443514
PubMed 20028748
RGD 1310200
UniProt O75717
Wiki WDHD1
The deduced 1,127-amino acid, 125-kD protein contains 7 WD repeats and a C-terminal HMG box. The HMG box is typical of some DNA-binding proteins involved in chromatin assembly, transcription, and replication. And1 also has several putative nuclear localization signals. And1 localized throughout the entire interchromatinic space of the interphase nucleoplasm, probably in homodimeric form. During mitosis, it was transiently dispersed over the cytoplasm. PCR of human cDNA libraries detected expression in brain, epidermis, liver, and stomach.By DNA affinity chromatography and electrophoretic mobility shift assays, Kohler et al. (1997) demonstrated that Xenopus And1 bound DNA.The International Radiation Hybrid Mapping Consortium mapped the AND1 gene to chromosome 14.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant WD Repeat And HMG Box DNA Binding Protein 1 (WDHD1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to WD Repeat And HMG Box DNA Binding Protein 1 (WDHD1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to WD Repeat And HMG Box DNA Binding Protein 1 (WDHD1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for WD Repeat And HMG Box DNA Binding Protein 1 (WDHD1) CLIA Kit Customized Service Offer
n/a ELISA Kit for WD Repeat And HMG Box DNA Binding Protein 1 (WDHD1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant WD Repeat And HMG Box DNA Binding Protein 1 (WDHD1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to WD Repeat And HMG Box DNA Binding Protein 1 (WDHD1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to WD Repeat And HMG Box DNA Binding Protein 1 (WDHD1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for WD Repeat And HMG Box DNA Binding Protein 1 (WDHD1) CLIA Kit Customized Service Offer
n/a ELISA Kit for WD Repeat And HMG Box DNA Binding Protein 1 (WDHD1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant WD Repeat And HMG Box DNA Binding Protein 1 (WDHD1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to WD Repeat And HMG Box DNA Binding Protein 1 (WDHD1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to WD Repeat And HMG Box DNA Binding Protein 1 (WDHD1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for WD Repeat And HMG Box DNA Binding Protein 1 (WDHD1) CLIA Kit Customized Service Offer
n/a ELISA Kit for WD Repeat And HMG Box DNA Binding Protein 1 (WDHD1) ELISA Kit Customized Service Offer
  1. "The DNA sequence and analysis of human chromosome 14." Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  3. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  4. "Mcm10 and And-1/CTF4 recruit DNA polymerase alpha to chromatin for initiation of DNA replication."Genes Dev. 21:2288-2299(2007) [PubMed] [Europe PMC] [Abstract]
  5. "ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage."Science 316:1160-1166(2007) [PubMed] [Europe PMC] [Abstract]
  6. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  7. "Assembly of the Cdc45-Mcm2-7-GINS complex in human cells requires the Ctf4/And-1, RecQL4, and Mcm10 proteins."Proc. Natl. Acad. Sci. U.S.A. 106:15628-15632(2009) [PubMed] [Europe PMC] [Abstract]
  8. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  9. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
  10. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  11. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  12. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  13. "Okazaki fragment processing-independent role for human Dna2 enzyme during DNA replication."J. Biol. Chem. 287:21980-21991(2012) [PubMed] [Europe PMC] [Abstract]
  14. "Solution structure of the HMG box domain from human WD repeat and HMG-box DNA binding protein 1."Submitted (MAY-2006) to the PDB data bank