Eomesodermin (EOMES)
EOMES encodes a member of a conserved protein family that shares a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. A similiar gene disrupted in mice is shown to be essential during trophoblast development and gastrulation.
Mutations in the mouse T (Brachyury) gene cause defects in mesoderm formation. Several related genes, members of the T-box gene family, encode a similar N-terminal DNA-binding domain, the T-box, and play critical roles in human embryonic development. Mutations in human TBX5 and TBX3, for example, cause the developmental disorders Holt-Oram syndrome and ulnar-mammary syndrome, respectively.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPK459Hu01 Recombinant Eomesodermin (EOMES) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAK459Hu01 Polyclonal Antibody to Eomesodermin (EOMES) WB; IHC; ICC; IP.
MAK459Hu21 Monoclonal Antibody to Eomesodermin (EOMES) WB; IHC; ICC; IP.
Assay Kits SEK459Hu ELISA Kit for Eomesodermin (EOMES) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Eomesodermin (EOMES) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Eomesodermin (EOMES) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Eomesodermin (EOMES) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Eomesodermin (EOMES) CLIA Kit Customized Service Offer
n/a ELISA Kit for Eomesodermin (EOMES) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Eomesodermin (EOMES) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Eomesodermin (EOMES) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Eomesodermin (EOMES) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Eomesodermin (EOMES) CLIA Kit Customized Service Offer
n/a ELISA Kit for Eomesodermin (EOMES) ELISA Kit Customized Service Offer
  1. "A novel mammalian T-box-containing gene, Tbr2, expressed in mouse developing brain."Brain Res. Dev. Brain Res. 115:183-193(1999) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "Exploration of human ORFeome: high-throughput preparation of ORF clones and efficient characterization of their protein products."DNA Res. 15:137-149(2008) [PubMed] [Europe PMC] [Abstract]
  4. "The DNA sequence, annotation and analysis of human chromosome 3." Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
  5. "Identification, mapping and phylogenomic analysis of four new human members of the T-box gene family: EOMES, TBX6, TBX18, and TBX19."Genomics 55:10-20(1999) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "The T-box transcription factor eomesodermin controls CD8 T cell activity and lymph node metastasis in human colorectal cancer."Gut 56:1572-1578(2007) [PubMed] [Europe PMC] [Abstract]
  8. "Homozygous silencing of T-box transcription factor EOMES leads to microcephaly with polymicrogyria and corpus callosum agenesis."Nat. Genet. 39:454-456(2007) [PubMed] [Europe PMC] [Abstract]
  9. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  10. "The consensus coding sequences of human breast and colorectal cancers." Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]