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DEAH Box Polypeptide 8 (DHX8)

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DDX8; HRH1; PRP22; PRPF22; DEAH(Asp-Glu-Ala-His)Box Polypeptide 8; RNA helicase HRH1

DEAH Box Polypeptide 8 (DHX8)
CCC K444
HGNC 2749
MGI 1306823
PubMed 22404213
RGD 1310723
UniProt Q14562
DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division.
DHX8encodes a DEAD box protein, which is highly homologous to yeast Prp22. DHX8 facilitates nuclear export of spliced mRNA by releasing the RNA from the spliceosome.The official designation for this gene is DDX8. Expression of DDX8 in a yeast PRP22 mutant partially rescued its temperature-sensitive phenotype. DDX8, but not PRP22, contained an arginine- and serine-rich domain (RS domain) that is characteristic of some splicing factors.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant DEAH Box Polypeptide 8 (DHX8) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to DEAH Box Polypeptide 8 (DHX8) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to DEAH Box Polypeptide 8 (DHX8) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for DEAH Box Polypeptide 8 (DHX8) CLIA Kit Customized Service Offer
n/a ELISA Kit for DEAH Box Polypeptide 8 (DHX8) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant DEAH Box Polypeptide 8 (DHX8) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to DEAH Box Polypeptide 8 (DHX8) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to DEAH Box Polypeptide 8 (DHX8) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for DEAH Box Polypeptide 8 (DHX8) CLIA Kit Customized Service Offer
n/a ELISA Kit for DEAH Box Polypeptide 8 (DHX8) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant DEAH Box Polypeptide 8 (DHX8) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to DEAH Box Polypeptide 8 (DHX8) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to DEAH Box Polypeptide 8 (DHX8) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for DEAH Box Polypeptide 8 (DHX8) CLIA Kit Customized Service Offer
n/a ELISA Kit for DEAH Box Polypeptide 8 (DHX8) ELISA Kit Customized Service Offer
  1. "Identification of a putative RNA helicase (HRH1), a human homolog of yeast Prp22."Mol. Cell. Biol. 14:7611-7620(1994) [PubMed] [Europe PMC] [Abstract]
  2. "A human RNA helicase-like protein, HRH1, facilitates nuclear export of spliced mRNA by releasing the RNA from the spliceosome."Genes Dev. 10:997-1007(1996) [PubMed] [Europe PMC] [Abstract]
  3. "Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis."RNA 8:426-439(2002) [PubMed] [Europe PMC] [Abstract]
  4. "Novel function of beta-arrestin2 in the nucleus of mature spermatozoa."J. Cell Sci. 119:3047-3056(2006) [PubMed] [Europe PMC] [Abstract]
  5. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  6. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  7. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  8. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  9. "Solution structure of the S1 RNA binding domain of human ATP-dependent RNA helicase DHX8."Submitted (OCT-2007) to the PDB data bank