≡

DEAH Box Polypeptide 36 (DHX36)

[Edit]

MLEL1; DDX36; G4R1; RHAU; DEAH(Asp-Glu-Ala-His)Box Polypeptide 36; G4-resolvase 1; MLE-like protein 1; RNA helicase associated with AU-rich element ARE

DEAH Box Polypeptide 36 (DHX36)
CCC K442
HGNC 14410
MGI 1919412
PubMed 21703541
RGD 1308767
UniProt Q9H2U1
Wiki DHX36
DHX36 is a member of the DEAH-box family of RNA-dependent NTPases which are named after the conserved amino acid sequence Asp-Glu-Ala-His in motif II. The protein encoded by this gene has been shown to enhance the deadenylation and decay of mRNAs with 3'-UTR AU-rich elements (ARE-mRNA). The protein has also been shown to resolve into single strands the highly stable tetramolecular DNA configuration (G4) that can form spontaneously in guanine-rich regions of DNA. DHX36 showed robust G4-DNA resolving activity. Formation of DNA monomers by DHX36 required ATP and Mg(2+). DHX36 did not resolve Y-form duplex DNA or duplex DNA with 5-prime or 3-prime overhangs. DHX36 readily resolved ribosomal G4-DNA.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant DEAH Box Polypeptide 36 (DHX36) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to DEAH Box Polypeptide 36 (DHX36) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to DEAH Box Polypeptide 36 (DHX36) Polyclonal Antibody Customized Service Offer
Assay Kits SEK442Hu ELISA Kit for DEAH Box Polypeptide 36 (DHX36) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant DEAH Box Polypeptide 36 (DHX36) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to DEAH Box Polypeptide 36 (DHX36) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to DEAH Box Polypeptide 36 (DHX36) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for DEAH Box Polypeptide 36 (DHX36) CLIA Kit Customized Service Offer
n/a ELISA Kit for DEAH Box Polypeptide 36 (DHX36) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant DEAH Box Polypeptide 36 (DHX36) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to DEAH Box Polypeptide 36 (DHX36) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to DEAH Box Polypeptide 36 (DHX36) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for DEAH Box Polypeptide 36 (DHX36) CLIA Kit Customized Service Offer
n/a ELISA Kit for DEAH Box Polypeptide 36 (DHX36) ELISA Kit Customized Service Offer
  1. "Molecular cloning and characterization of human DDX36 and mouse Ddx36 genes, new members of the DEAD/H box superfamily."Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao 34:655-661(2002) [PubMed] [Europe PMC] [Abstract]
  2. "Facilitation of mRNA deadenylation and decay by the exosome-bound, DExH protein RHAU."Mol. Cell 13:101-111(2004) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The DNA sequence, annotation and analysis of human chromosome 3." Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."DNA Res. 7:143-150(2000) [PubMed] [Europe PMC] [Abstract]
  7. "The DEXH protein product of the DHX36 gene is the major source of tetramolecular quadruplex G4-DNA resolving activity in HeLa cell lysates."J. Biol. Chem. 280:38117-38120(2005) [PubMed] [Europe PMC] [Abstract]
  8. "Proteomic and functional analysis of Argonaute-containing mRNA-protein complexes in human cells."EMBO Rep. 8:1052-1060(2007) [PubMed] [Europe PMC] [Abstract]
  9. "G4 resolvase 1 binds both DNA and RNA tetramolecular quadruplex with high affinity and is the major source of tetramolecular quadruplex G4-DNA and G4-RNA resolving activity in HeLa cell lysates."J. Biol. Chem. 283:34626-34634(2008) [PubMed] [Europe PMC] [Abstract]
  10. "Recruitment of the RNA helicase RHAU to stress granules via a unique RNA-binding domain."J. Biol. Chem. 283:35186-35198(2008) [PubMed] [Europe PMC] [Abstract]
  11. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  12. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  13. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
  14. "Role of the amino terminal RHAU-specific motif in the recognition and resolution of guanine quadruplex-RNA by the DEAH-box RNA helicase RHAU."Nucleic Acids Res. 38:6219-6233(2010) [PubMed] [Europe PMC] [Abstract]
  15. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  16. "The 5' guanosine tracts of human telomerase RNA are recognized by the G-quadruplex binding domain of the RNA helicase DHX36 and function to increase RNA accumulation."Mol. Cell. Biol. 31:736-743(2011) [PubMed] [Europe PMC] [Abstract]
  17. "G4 resolvase 1 tightly binds and unwinds unimolecular G4-DNA."Nucleic Acids Res. 39:7161-7178(2011) [PubMed] [Europe PMC] [Abstract]
  18. "Yin Yang 1 contains G-quadruplex structures in its promoter and 5'-UTR and its expression is modulated by G4 resolvase 1."Nucleic Acids Res. 40:1033-1049(2012) [PubMed] [Europe PMC] [Abstract]
  19. "The RNA helicase RHAU (DHX36) unwinds a G4-quadruplex in human telomerase RNA and promotes the formation of the P1 helix template boundary."Nucleic Acids Res. 40:4110-4124(2012) [PubMed] [Europe PMC] [Abstract]