≡

Elongation Protein 2 (ELP2)

[Edit]

STATIP1; StIP; SHINC-2; Signal Transducer And Activator Of Transcription 3 Interacting Protein 1; Elongator Complex Protein 2; STAT3-interacting protein 1

Elongation Protein 2 (ELP2)
CCC K436
HGNC 18248
MGI 1889642
PubMed 11714725
RGD 1306419
UniProt Q6IA86
Wiki ELP2
Elongator complex protein 2 is a protein that in humans is encoded by the ELP2 gene. Component of the RNA polymerase II elongator complex (Elongator), which consists of IKBKAP/ELP1, STIP1/ELP2, ELP3, ELP4, and two yet unidentified proteins, p30 and p38. Elongator associates with the C-terminal domain (CTD) of Pol II largest subunit. Interacts with STAT3 and JAKs. Acts as subunit of the RNA polymerase II elongator complex, which is a histone acetyltransferase component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation. Elongator may play a role in chromatin remodeling and is involved in acetylation of histones H3 and probably H4.Regulates the ligand-dependent activation of STAT3 .

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Elongation Protein 2 (ELP2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Elongation Protein 2 (ELP2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Elongation Protein 2 (ELP2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Elongation Protein 2 (ELP2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Elongation Protein 2 (ELP2) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Elongation Protein 2 (ELP2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Elongation Protein 2 (ELP2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Elongation Protein 2 (ELP2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Elongation Protein 2 (ELP2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Elongation Protein 2 (ELP2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Elongation Protein 2 (ELP2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Elongation Protein 2 (ELP2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Elongation Protein 2 (ELP2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Elongation Protein 2 (ELP2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Elongation Protein 2 (ELP2) ELISA Kit Customized Service Offer
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  2. "DNA sequence and analysis of human chromosome 18." Nature 437:551-555(2005) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Purification and characterization of the human elongator complex."J. Biol. Chem. 277:3047-3052(2002) [PubMed] [Europe PMC] [Abstract]
  5. "Human Elongator facilitates RNA polymerase II transcription through chromatin."Proc. Natl. Acad. Sci. U.S.A. 99:1241-1246(2002) [PubMed] [Europe PMC] [Abstract]
  6. "DERP6 (ELP5) and C3ORF75 (ELP6) regulate tumorigenicity and migration of melanoma cells as subunits of Elongator."J. Biol. Chem. 287:32535-32545(2012) [PubMed] [Europe PMC] [Abstract]