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PHD Finger Protein 17 (PHF17)

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JADE1; Jade family PHD finger protein 1

PHD Finger Protein 17 (PHF17)
CCC K426
HGNC 30027
MGI 1925835
PubMed 22974136
RGD 1306920
UniProt Q6IE81
Wiki PHF17
The deduced 702-amino acid protein shares significant similarity with the human zinc finger protein BR140 (BRPF1). RT-PCR ELISA detected very high expression in whole adult brain and intermediate expression in all other tissues examined, including all specific brain regions tested.JADE1 could activate transcription and that deletion of the PHD zinc fingers abolished transcriptional activity. JADE1 also promoted histone H4, but not histone H3 acetylation in a dose-dependent manner, and acetylation required the PHDs. A JADE1 mutant lacking the second PHD behaved in a dominant-negative manner. TIP60 (HTATIP), a histone acetyltransferase with histone H4/H2A specificity, physically associated with JADE1 and augmented JADE1 acetyltransferase function.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant PHD Finger Protein 17 (PHF17) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to PHD Finger Protein 17 (PHF17) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to PHD Finger Protein 17 (PHF17) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for PHD Finger Protein 17 (PHF17) CLIA Kit Customized Service Offer
n/a ELISA Kit for PHD Finger Protein 17 (PHF17) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant PHD Finger Protein 17 (PHF17) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to PHD Finger Protein 17 (PHF17) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to PHD Finger Protein 17 (PHF17) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for PHD Finger Protein 17 (PHF17) CLIA Kit Customized Service Offer
n/a ELISA Kit for PHD Finger Protein 17 (PHF17) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant PHD Finger Protein 17 (PHF17) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to PHD Finger Protein 17 (PHF17) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to PHD Finger Protein 17 (PHF17) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for PHD Finger Protein 17 (PHF17) CLIA Kit Customized Service Offer
n/a ELISA Kit for PHD Finger Protein 17 (PHF17) ELISA Kit Customized Service Offer
  1. "The von Hippel-Lindau tumor suppressor stabilizes novel plant homeodomain protein Jade-1."J. Biol. Chem. 277:39887-39898(2002) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."DNA Res. 8:85-95(2001) [PubMed] [Europe PMC] [Abstract]
  6. "Identification of Jade1, a gene encoding a PHD zinc finger protein, in a gene trap mutagenesis screen for genes involved in anteroposterior axis development."Mol. Cell. Biol. 23:8553-8562(2003) [PubMed] [Europe PMC] [Abstract]
  7. "von Hippel-Lindau partner Jade-1 is a transcriptional co-activator associated with histone acetyltransferase activity."J. Biol. Chem. 279:56032-56041(2004) [PubMed] [Europe PMC] [Abstract]
  8. "Jade-1, a candidate renal tumor suppressor that promotes apoptosis."Proc. Natl. Acad. Sci. U.S.A. 102:11035-11040(2005) [PubMed] [Europe PMC] [Abstract]
  9. "ING tumor suppressor proteins are critical regulators of chromatin acetylation required for genome expression and perpetuation."Mol. Cell 21:51-64(2006) [PubMed] [Europe PMC] [Abstract]
  10. "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
  11. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  12. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  13. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  14. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]