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VPS33B Interacting Protein, Apical Basolateral Polarity Regulator (VIPAR)

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VPS16B; SPE39; C14orf133; VIPAS39; Spermatogenesis-defective protein 39 homolog; VPS33B-interacting protein in polarity and apical restriction

VPS33B Interacting Protein, Apical Basolateral Polarity Regulator (VIPAR)
CCC K409
HGNC 20347
MGI 2144805
PubMed 20190753
UniProt Q9H9C1
VIPAR, had highest priority based on bioinformatic analyses of homology and putative function. Coimmunoprecipitation studies in transfected HEK293 cells confirmed the interaction between overexpressed VPS33B and VIPAR, with formation of functional VPS33B-VIPAR complexes at cytoplasmic organelles that interacted with RAB11A. Knockdown of vipar in zebrafish resulted in biliary excretion and E-cadherin (CDH1) defects similar to those in individuals with ARC syndrome caused by mutation in VPS33B or VIPAR (see MOLECULAR GENETICS section).
Vipar- and Vps33b-deficient mouse inner medullary collecting duct (mIMCD-3) cells expressed membrane proteins abnormally and had structural and functional tight junction defects.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant VPS33B Interacting Protein, Apical Basolateral Polarity Regulator (VIPAR) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to VPS33B Interacting Protein, Apical Basolateral Polarity Regulator (VIPAR) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to VPS33B Interacting Protein, Apical Basolateral Polarity Regulator (VIPAR) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for VPS33B Interacting Protein, Apical Basolateral Polarity Regulator (VIPAR) CLIA Kit Customized Service Offer
n/a ELISA Kit for VPS33B Interacting Protein, Apical Basolateral Polarity Regulator (VIPAR) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant VPS33B Interacting Protein, Apical Basolateral Polarity Regulator (VIPAR) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to VPS33B Interacting Protein, Apical Basolateral Polarity Regulator (VIPAR) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to VPS33B Interacting Protein, Apical Basolateral Polarity Regulator (VIPAR) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for VPS33B Interacting Protein, Apical Basolateral Polarity Regulator (VIPAR) CLIA Kit Customized Service Offer
n/a ELISA Kit for VPS33B Interacting Protein, Apical Basolateral Polarity Regulator (VIPAR) ELISA Kit Customized Service Offer
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  2. "The DNA sequence and analysis of human chromosome 14." Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  5. "SPE-39 family proteins interact with the HOPS complex and function in lysosomal delivery."Mol. Biol. Cell 20:1223-1240(2009) [PubMed] [Europe PMC] [Abstract]
  6. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  7. "Mutations in VIPAR cause an arthrogryposis, renal dysfunction and cholestasis syndrome phenotype with defects in epithelial polarization." Nat. Genet. 42:303-312(2010) [PubMed] [Europe PMC] [Abstract]
  8. "On the endosomal function and gene nomenclature of human SPE-39."Nat. Genet. 43:176-176(2011) [PubMed] [Europe PMC] [Abstract]
  9. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]