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TBK1 Binding Protein 1 (TBKBP1)

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SINTBAD; ProSAPiP2; TANK-binding kinase 1-binding protein 1

TBK1 Binding Protein 1 (TBKBP1)
CCC K408
HGNC 30140
MGI 1920424
PubMed 23637848
RGD 631328
UniProt A7MCY6
TBKBP1 is an adaptor protein that binds to TBK1 and is part of the interaction network in the TNF /NFKB pathway.The NF-kappa-B (NFKB) complex of proteins is inhibited by I-kappa-B (IKB) proteins, which inactivate NFKB by trapping it in the cytoplasm.
By searching for sequences with the potential to encode large proteins expressed in brain, Nagase et al. (1998) identified a cDNA encoding KIAA0775. The predicted protein contains 615 amino acids. RT-PCR analysis detected ubiquitous expression, with highest levels in ovary, followed by testis, brain, heart, lung, smooth muscle, kidney, and liver. The International Radiation Hybrid Mapping Consortium mapped the TBKBP1 gene to chromosome 17 (WI-14964).

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant TBK1 Binding Protein 1 (TBKBP1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to TBK1 Binding Protein 1 (TBKBP1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to TBK1 Binding Protein 1 (TBKBP1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for TBK1 Binding Protein 1 (TBKBP1) CLIA Kit Customized Service Offer
n/a ELISA Kit for TBK1 Binding Protein 1 (TBKBP1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant TBK1 Binding Protein 1 (TBKBP1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to TBK1 Binding Protein 1 (TBKBP1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to TBK1 Binding Protein 1 (TBKBP1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for TBK1 Binding Protein 1 (TBKBP1) CLIA Kit Customized Service Offer
n/a ELISA Kit for TBK1 Binding Protein 1 (TBKBP1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant TBK1 Binding Protein 1 (TBKBP1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to TBK1 Binding Protein 1 (TBKBP1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to TBK1 Binding Protein 1 (TBKBP1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for TBK1 Binding Protein 1 (TBKBP1) CLIA Kit Customized Service Offer
n/a ELISA Kit for TBK1 Binding Protein 1 (TBKBP1) ELISA Kit Customized Service Offer
  1. "Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."DNA Res. 5:277-286(1998) [PubMed] [Europe PMC] [Abstract].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  3. "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway." Nat. Cell Biol. 6:97-105(2004) [PubMed] [Europe PMC] [Abstract]
  4. "SINTBAD, a novel component of innate antiviral immunity, shares a TBK1-binding domain with NAP1 and TANK."EMBO J. 26:3180-3190(2007) [PubMed] [Europe PMC] [Abstract]
  5. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  6. "Large-scale proteomics analysis of the human kinome."Mol. Cell. Proteomics 8:1751-1764(2009) [PubMed] [Europe PMC] [Abstract]
  7. "Functional dissection of the TBK1 molecular network."PLoS ONE 6:E23971-E23971(2011) [PubMed] [Europe PMC] [Abstract]
  8. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]