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Kelch Like Protein 13 (KLHL13)

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BKLHD2; BTB And Kelch Domain Containing 2

Kelch Like Protein 13 (KLHL13)
CCC K391
HGNC 22931
MGI 1914705
PubMed 17543862
RGD 1559646
UniProt Q9P2N7
KLHL13 functions as an adaptor protein that complexes with Cullin 3 and other proteins to form the Cullin 3-based E3 ubiquitin-protein ligase complex. This complex is necessary for proper chromosome segregation and completion of cytokinesis. Alternate splicing results in multiple transcript variants.
The CUL3/KLHL9/KLHL13 complex was the minimum unit required for correct chromosome alignment in metaphase, proper midzone and midbody formation, and completion of cytokinesis. CUL3/KLHL9/KLHL13 acted as an E3 ligase and regulated dynamic localization of the chromosomal passenger protein Aurora B (AURKB) on mitotic chromosomes and accumulation of Aurora B on the central spindle after anaphase onset.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Kelch Like Protein 13 (KLHL13) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Kelch Like Protein 13 (KLHL13) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Kelch Like Protein 13 (KLHL13) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Kelch Like Protein 13 (KLHL13) CLIA Kit Customized Service Offer
n/a ELISA Kit for Kelch Like Protein 13 (KLHL13) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Kelch Like Protein 13 (KLHL13) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Kelch Like Protein 13 (KLHL13) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Kelch Like Protein 13 (KLHL13) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Kelch Like Protein 13 (KLHL13) CLIA Kit Customized Service Offer
n/a ELISA Kit for Kelch Like Protein 13 (KLHL13) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Kelch Like Protein 13 (KLHL13) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Kelch Like Protein 13 (KLHL13) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Kelch Like Protein 13 (KLHL13) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Kelch Like Protein 13 (KLHL13) CLIA Kit Customized Service Offer
n/a ELISA Kit for Kelch Like Protein 13 (KLHL13) ELISA Kit Customized Service Offer
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  7. "The Cul3-KLHL21 E3 ubiquitin ligase targets aurora B to midzone microtubules in anaphase and is required for cytokinesis."J. Cell Biol. 187:791-800(2009) [PubMed] [Europe PMC] [Abstract]
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