Family With Sequence Similarity 9, Member C (FAM9C)

By characterizing a region of chromosome Xp22 involved in a translocation with chromosome 10, followed by EST database analysis and 5-prime RACE of a testis cDNA library, Martinez-Garay et al. (2002) cloned full-length FAM9C. The deduced 166-amino acid protein shares 65% amino acid identity with FAM9B, 59% identity with FAM9A, and about 30% identity with rodent Sycp3. Northern blot analysis of several tissues detected FAM9C expression only in testis. Fluorescence-tagged FAM9C localized primarily to the nucleus of transfected COS-7 cells.

Martinez-Garay et al. (2002) determined that the FAM9C gene contains 8 exons and spans about 9.0 kb.By genomic sequence analysis, Martinez-Garay et al. (2002) mapped the FAM9C gene to chromosome Xp22.31, near the FAM9A and FAM9B genes and several pseudogenes.