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Family With Sequence Similarity 20, Member A (FAM20A)

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Family With Sequence Similarity 20, Member A (FAM20A)
CCC K371
HGNC 23015
MGI 2388266
PubMed 23434854
RGD 1306364
UniProt Q96MK3
Wiki FAM20A
By database searching, they determined that this protein is a member of a family of related proteins with 2 other members in mammals: FAM20B and FAM20C. All FAM20 proteins contain putative conserved signal sequences as well as a conserved C-terminal domain. Fam20a-GFP fusion proteins displayed perinuclear and cytoplasmic staining consistent with localization in the endoplasmic reticulum. Transfection experiments in COS-1 cells demonstrated that Fam20a is a secreted glycoprotein, and immunofluorescence studies showed that an intact signal sequence is required for secretion. Examination of the expression pattern of FAM20A from a panel of cDNAs derived from various human tissues revealed high levels in lung and liver and intermediate levels in thymus and ovary.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPK371Hu01 Recombinant Family With Sequence Similarity 20, Member A (FAM20A) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAK371Hu01 Polyclonal Antibody to Family With Sequence Similarity 20, Member A (FAM20A) WB; IHC; ICC; IP.
MAK371Hu21 Monoclonal Antibody to Family With Sequence Similarity 20, Member A (FAM20A) WB; IHC; ICC; IP.
Assay Kits SEK371Hu ELISA Kit for Family With Sequence Similarity 20, Member A (FAM20A) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Family With Sequence Similarity 20, Member A (FAM20A) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Family With Sequence Similarity 20, Member A (FAM20A) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Family With Sequence Similarity 20, Member A (FAM20A) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Family With Sequence Similarity 20, Member A (FAM20A) CLIA Kit Customized Service Offer
n/a ELISA Kit for Family With Sequence Similarity 20, Member A (FAM20A) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Family With Sequence Similarity 20, Member A (FAM20A) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Family With Sequence Similarity 20, Member A (FAM20A) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Family With Sequence Similarity 20, Member A (FAM20A) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Family With Sequence Similarity 20, Member A (FAM20A) CLIA Kit Customized Service Offer
n/a ELISA Kit for Family With Sequence Similarity 20, Member A (FAM20A) ELISA Kit Customized Service Offer
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  2. "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
  3. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage." Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  6. "FAM20: an evolutionarily conserved family of secreted proteins expressed in hematopoietic cells."BMC Genomics 6:11-11(2005) [PubMed] [Europe PMC] [Abstract]
  7. "Whole-exome sequencing identifies FAM20A mutations as a cause of amelogenesis imperfecta and gingival hyperplasia syndrome."Am. J. Hum. Genet. 88:616-620(2011) [PubMed] [Europe PMC] [Abstract]
  8. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  9. "Novel FAM20A mutations in hypoplastic amelogenesis imperfecta."Hum. Mutat. 33:91-94(2012) [PubMed] [Europe PMC] [Abstract]
  10. "Nephrocalcinosis (enamel renal syndrome) caused by autosomal recessive FAM20A mutations." Nephron Physiol. 122:1-6(2012) [PubMed] [Europe PMC] [Abstract]
  11. "FAM20A mutations can cause enamel-renal syndrome (ERS)."PLoS Genet. 9:E1003302-E1003302(2013) [PubMed] [Europe PMC] [Abstract]
  12. "FAM20A mutations associated with enamel renal syndrome."J. Dent. Res. 93:42-48(2014) [PubMed] [Europe PMC] [Abstract]