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Ecotropic Viral Integration Site 1 (EVI1)

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MDS1; MDS1-EVI1; PRDM3; MECOM; Myelodysplasia Syndrome 1; MDS1 And EVI1 Complex Locus

Ecotropic Viral Integration Site 1 (EVI1)
CCC K367
HGNC 3498
MGI 95457
PubMed 21289308
RGD 1310997
UniProt Q03112
Wiki EVI1
The murine Evi1 gene encodes a protein that has multiple 28-amino acid repeats containing the consensus sequence found in the zinc finger domains of many transcriptional regulatory proteins. Activation of the expression of the Evi1 gene is frequently found in murine myeloid leukemias and leukemia cell lines and is due to retroviral insertions in the 5-prime region of the gene.
By in situ hybridization with metaphase chromosomes from a patient with a 3;5 translocation, they found that the EVI1 gene was translocated to the derivative chromosome 5. However, no rearrangements were detected by Southern blot analysis and no EVI1 transcripts were detected with RNA from leukemic blasts of 1 patient with the translocation.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Ecotropic Viral Integration Site 1 (EVI1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Ecotropic Viral Integration Site 1 (EVI1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ecotropic Viral Integration Site 1 (EVI1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Ecotropic Viral Integration Site 1 (EVI1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ecotropic Viral Integration Site 1 (EVI1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Ecotropic Viral Integration Site 1 (EVI1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Ecotropic Viral Integration Site 1 (EVI1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ecotropic Viral Integration Site 1 (EVI1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Ecotropic Viral Integration Site 1 (EVI1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ecotropic Viral Integration Site 1 (EVI1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Ecotropic Viral Integration Site 1 (EVI1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Ecotropic Viral Integration Site 1 (EVI1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ecotropic Viral Integration Site 1 (EVI1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Ecotropic Viral Integration Site 1 (EVI1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ecotropic Viral Integration Site 1 (EVI1) ELISA Kit Customized Service Offer
  1. "Unique expression of the human Evi-1 gene in an endometrial carcinoma cell line: sequence of cDNAs and structure of alternatively spliced transcripts."Oncogene 5:963-971(1990) [PubMed] [Europe PMC] [Abstract]
  2. "Generation of the AML1-EVI-1 fusion gene in the t(3;21)(q26;q22) causes blastic crisis in chronic myelocytic leukemia."EMBO J. 13:504-510(1994) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  5. "The DNA sequence, annotation and analysis of human chromosome 3." Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Structurally altered Evi-1 protein generated in the 3q21q26 syndrome."Oncogene 13:183-191(1996) [PubMed] [Europe PMC] [Abstract]
  8. "The oncoprotein Evi-1 represses TGF-beta signalling by inhibiting Smad3."Nature 394:92-96(1998) [PubMed] [Europe PMC] [Abstract]
  9. "The evi-1 oncoprotein inhibits c-Jun N-terminal kinase and prevents stress-induced cell death."EMBO J. 19:2958-2968(2000) [PubMed] [Europe PMC] [Abstract]
  10. "Interaction of EVI1 with cAMP-responsive element-binding protein-binding protein (CBP) and p300/CBP-associated factor (P/CAF) results in reversible acetylation of EVI1 and in co-localization in nuclear speckles."J. Biol. Chem. 276:44936-44943(2001) [PubMed] [Europe PMC] [Abstract]
  11. "Oligomerization of Evi-1 regulated by the PR domain contributes to recruitment of corepressor CtBP."Oncogene 24:6165-6173(2005) [PubMed] [Europe PMC] [Abstract]
  12. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  13. "Evi1 is a survival factor which conveys resistance to both TGFbeta- and taxol-mediated cell death via PI3K/AKT."Oncogene 25:3565-3575(2006) [PubMed] [Europe PMC] [Abstract]
  14. "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
  15. "Pbx1 is a downstream target of Evi-1 in hematopoietic stem/progenitors and leukemic cells."Oncogene 28:4364-4374(2009) [PubMed] [Europe PMC] [Abstract]
  16. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]