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Protein Kinase, DNA Activated, Catalytic Polypeptide (PRKDC)

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HYRC; HYRC1; DNPK1; p350; DNAPK; XRCC7; DNA-PKcs

Protein Kinase, DNA Activated, Catalytic Polypeptide (PRKDC)
CCC K362
HGNC 9413
MGI 104779
PubMed 22499342
RGD 1308982
UniProt P78527
Wiki PRKDC
The PRKDC gene encodes the catalytic subunit of a nuclear DNA-dependent serine/threonine protein kinase (DNA-PK). The second component is the autoimmune antigen Ku, which is encoded by the G22P1 gene on chromosome 22q. On its own, the catalytic subunit of DNA-PK is inactive and relies on the G22P1 component to direct it to the DNA and trigger its kinase activity; PRKDC must be bound to DNA to express its catalytic properties. The PRKDC protein showed similarity to phosphatidylinositol 3-kinase family members involved in cell cycle control, DNA repair, and DNA damage responses, and had no detectable activity towards lipids. Other PI kinase proteins involved in DNA repair include FKBP12 and the ataxia-telangiectasia gene (ATM), in which mutations lead to genomic instability and predisposition to cancer and ataxia.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPK362Hu01 Recombinant Protein Kinase, DNA Activated, Catalytic Polypeptide (PRKDC) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAK362Hu01 Polyclonal Antibody to Protein Kinase, DNA Activated, Catalytic Polypeptide (PRKDC) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Protein Kinase, DNA Activated, Catalytic Polypeptide (PRKDC) CLIA Kit Customized Service Offer
n/a ELISA Kit for Protein Kinase, DNA Activated, Catalytic Polypeptide (PRKDC) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPK362Mu01 Recombinant Protein Kinase, DNA Activated, Catalytic Polypeptide (PRKDC) Positive Control; Immunogen; SDS-PAGE; WB.
RPK362Mu02 Recombinant Protein Kinase, DNA Activated, Catalytic Polypeptide (PRKDC) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAK362Mu01 Polyclonal Antibody to Protein Kinase, DNA Activated, Catalytic Polypeptide (PRKDC) WB; IHC; ICC; IP.
PAK362Mu02 Polyclonal Antibody to Protein Kinase, DNA Activated, Catalytic Polypeptide (PRKDC) WB; IHC; ICC; IP.
Assay Kits SEK362Mu ELISA Kit for Protein Kinase, DNA Activated, Catalytic Polypeptide (PRKDC) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Protein Kinase, DNA Activated, Catalytic Polypeptide (PRKDC) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Protein Kinase, DNA Activated, Catalytic Polypeptide (PRKDC) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Protein Kinase, DNA Activated, Catalytic Polypeptide (PRKDC) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Protein Kinase, DNA Activated, Catalytic Polypeptide (PRKDC) CLIA Kit Customized Service Offer
n/a ELISA Kit for Protein Kinase, DNA Activated, Catalytic Polypeptide (PRKDC) ELISA Kit Customized Service Offer
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  60. "RNF144A, an E3 ubiquitin ligase for DNA-PKcs, promotes apoptosis during DNA damage."Proc. Natl. Acad. Sci. U.S.A. 111:E2646-E2655(2014) [PubMed] [Europe PMC] [Abstract]
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