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NLR Family, Member X1 (NLRX1)

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NOD9; CLR11.3; Caterpiller protein 11.3; Nucleotide-Binding Oligomerization Domain,Leucine Rich Repeat Containing X1; NOD-Like Receptor X1; NLR Family,X1

NLR Family, Member X1 (NLRX1)
CCC K351
HGNC 29890
MGI 2429611
PubMed 18200010
RGD 1311293
UniProt Q86UT6
Wiki NLRX1
NLRX1 localizes to the mitochondrial outer membrane and interacts with MAVS. Expression of NLRX1 results in the potent inhibition of RIG -like helicase (RLH) family and MAVS-mediated interferon-beta promoter activity and in the disruption of virus-induced RLH-MAVS interactions. Depletion of NLRX1 with small interference RNA promoted virus-induced type I interferon production and decreased viral replication.
NLRX1 contains a central putative NBD and carboxy-terminal LRRs. The amino terminus contains a mitochondrial targeting sequence and 2 transmembrane regions. NLRX1 homologs were identified in all vertebrates examined, with a remarkably high (92.4%) degree of conservation between human and mouse.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant NLR Family, Member X1 (NLRX1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to NLR Family, Member X1 (NLRX1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to NLR Family, Member X1 (NLRX1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for NLR Family, Member X1 (NLRX1) CLIA Kit Customized Service Offer
n/a ELISA Kit for NLR Family, Member X1 (NLRX1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant NLR Family, Member X1 (NLRX1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to NLR Family, Member X1 (NLRX1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to NLR Family, Member X1 (NLRX1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for NLR Family, Member X1 (NLRX1) CLIA Kit Customized Service Offer
n/a ELISA Kit for NLR Family, Member X1 (NLRX1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant NLR Family, Member X1 (NLRX1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to NLR Family, Member X1 (NLRX1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to NLR Family, Member X1 (NLRX1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for NLR Family, Member X1 (NLRX1) CLIA Kit Customized Service Offer
n/a ELISA Kit for NLR Family, Member X1 (NLRX1) ELISA Kit Customized Service Offer
  1. "NODs: intracellular proteins involved in inflammation and apoptosis."Nat. Rev. Immunol. 3:371-382(2003) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "NOD-LRR proteins: role in host-microbial interactions and inflammatory disease."Annu. Rev. Biochem. 74:355-383(2005) [PubMed] [Europe PMC] [Abstract]
  5. "CATERPILLER: a novel gene family important in immunity, cell death, and diseases."Annu. Rev. Immunol. 23:387-414(2005) [PubMed] [Europe PMC] [Abstract]
  6. "NLRX1 is a mitochondrial NOD-like receptor that amplifies NF-kappaB and JNK pathways by inducing reactive oxygen species production."EMBO Rep. 9:293-300(2008) [PubMed] [Europe PMC] [Abstract]
  7. "NLRX1 is a regulator of mitochondrial antiviral immunity."Nature 451:573-577(2008) [PubMed] [Europe PMC] [Abstract]
  8. "Structure and functional characterization of the RNA-binding element of the NLRX1 innate immune modulator."Immunity 36:337-347(2012) [PubMed] [Europe PMC] [Abstract]