Magnesium Transporter 1 (MAGT1)
[Edit]IAP; OST3B; MRX95; Oligosaccharyltransferase 3 Homolog B; Implantation-associated protein
MAGT1 encodes a magnesium cation transporter protein that localizes to the cell membrane. This protein also associates with N-oligosaccharyl transferase and therefore may have a role in N-glycosylation. Mutations in this gene cause mental retardation X-linked type 95 (MRX95). This gene may have multiple in-frame translation initiation sites, one of which would encode a shorter protein with an N-terminus containing a signal peptide at amino acids 1-29.The deduced 335-amino acid human protein has a calculated molecular mass of 38 kD. MAGT1 contains 5 putative transmembrane domains, the first of which is likely cleaved. It has an N-glycosylation site in its first extracellular loop and several putative phosphorylation sites in its N-terminal region. Northern blot analysis detected variable Magt1 expression in all mouse tissues examined. .
Organism species: Homo sapiens (Human)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | n/a | Recombinant Magnesium Transporter 1 (MAGT1) | Recombinant Protein Customized Service Offer |
Antibodies | n/a | Monoclonal Antibody to Magnesium Transporter 1 (MAGT1) | Monoclonal Antibody Customized Service Offer |
n/a | Polyclonal Antibody to Magnesium Transporter 1 (MAGT1) | Polyclonal Antibody Customized Service Offer | |
Assay Kits | n/a | CLIA Kit for Magnesium Transporter 1 (MAGT1) | CLIA Kit Customized Service Offer |
n/a | ELISA Kit for Magnesium Transporter 1 (MAGT1) | ELISA Kit Customized Service Offer |
Organism species: Mus musculus (Mouse)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | n/a | Recombinant Magnesium Transporter 1 (MAGT1) | Recombinant Protein Customized Service Offer |
Antibodies | n/a | Monoclonal Antibody to Magnesium Transporter 1 (MAGT1) | Monoclonal Antibody Customized Service Offer |
n/a | Polyclonal Antibody to Magnesium Transporter 1 (MAGT1) | Polyclonal Antibody Customized Service Offer | |
Assay Kits | n/a | CLIA Kit for Magnesium Transporter 1 (MAGT1) | CLIA Kit Customized Service Offer |
n/a | ELISA Kit for Magnesium Transporter 1 (MAGT1) | ELISA Kit Customized Service Offer |
Organism species: Rattus norvegicus (Rat)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | n/a | Recombinant Magnesium Transporter 1 (MAGT1) | Recombinant Protein Customized Service Offer |
Antibodies | n/a | Monoclonal Antibody to Magnesium Transporter 1 (MAGT1) | Monoclonal Antibody Customized Service Offer |
n/a | Polyclonal Antibody to Magnesium Transporter 1 (MAGT1) | Polyclonal Antibody Customized Service Offer | |
Assay Kits | n/a | CLIA Kit for Magnesium Transporter 1 (MAGT1) | CLIA Kit Customized Service Offer |
n/a | ELISA Kit for Magnesium Transporter 1 (MAGT1) | ELISA Kit Customized Service Offer |
- "Identification and characterization of a novel mammalian Mg2+ transporter with channel-like properties."BMC Genomics 6:48-48(2005) [PubMed] [Europe PMC] [Abstract]
- "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
- "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
- "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries." DNA Res. 12:117-126(2005) [PubMed] [Europe PMC] [Abstract]
- "Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs." Genome Res. 11:422-435(2001) [PubMed] [Europe PMC] [Abstract]
- "The DNA sequence of the human X chromosome." Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
- "Oligosaccharyltransferase isoforms that contain different catalytic STT3 subunits have distinct enzymatic properties."Mol. Cell 12:101-111(2003) [PubMed] [Europe PMC] [Abstract]
- "Mammalian MagT1 and TUSC3 are required for cellular magnesium uptake and vertebrate embryonic development."Proc. Natl. Acad. Sci. U.S.A. 106:15750-15755(2009) [PubMed] [Europe PMC] [Abstract]
- "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
- "Second messenger role for Mg2+ revealed by human T-cell immunodeficiency."Nature 475:471-476(2011) [PubMed] [Europe PMC] [Abstract]
- "Oligosaccharyltransferase-subunit mutations in nonsyndromic mental retardation."Am. J. Hum. Genet. 82:1150-1157(2008) [PubMed] [Europe PMC] [Abstract]
- "XLID-causing mutations and associated genes challenged in light of data from large-scale human exome sequencing."Am. J. Hum. Genet. 93:368-383(2013) [PubMed] [Europe PMC] [Abstract]