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Sin3A Associated Protein 45kDa (SAP45)

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SUDS3; SDS3; Suppressor Of Defective Silencing 3 Homolog; Sin3 histone deacetylase corepressor complex component SDS3

Sin3A Associated Protein 45kDa (SAP45)
CCC K337
HGNC 29545
MGI 1919204
PubMed 12724404
RGD 1305986
UniProt Q9H7L9
SDS3 is a subunit of the histone deacetylase-dependent SIN3A corepressor complex. Database analysis indicated that the deduced 328-amino acid protein shares 99.6% identity with human SDS3 and 18% identity with yeast Sds3.
Analysis of a panel of adult mouse tissues detected broad expression of a 2.4-kb transcript, as well as a 1.8-kb transcript arising from an alternative polyadenylation signal. Expression analysis revealed a nuclear staining pattern. Western blot analysis of Sds3 in transiently transfected human embryonic kidney cells revealed an apparent molecular mass of about 48 kD, with a less prominent band of 52 kD when overexpressed.The deduced protein contains 328 amino acids. Northern blot analysis detected SDS3 expression in all human cell lines examined

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Sin3A Associated Protein 45kDa (SAP45) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Sin3A Associated Protein 45kDa (SAP45) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Sin3A Associated Protein 45kDa (SAP45) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Sin3A Associated Protein 45kDa (SAP45) CLIA Kit Customized Service Offer
n/a ELISA Kit for Sin3A Associated Protein 45kDa (SAP45) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Sin3A Associated Protein 45kDa (SAP45) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Sin3A Associated Protein 45kDa (SAP45) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Sin3A Associated Protein 45kDa (SAP45) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Sin3A Associated Protein 45kDa (SAP45) CLIA Kit Customized Service Offer
n/a ELISA Kit for Sin3A Associated Protein 45kDa (SAP45) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Sin3A Associated Protein 45kDa (SAP45) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Sin3A Associated Protein 45kDa (SAP45) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Sin3A Associated Protein 45kDa (SAP45) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Sin3A Associated Protein 45kDa (SAP45) CLIA Kit Customized Service Offer
n/a ELISA Kit for Sin3A Associated Protein 45kDa (SAP45) ELISA Kit Customized Service Offer
  1. "Characterization of long cDNA clones from human adult spleen."DNA Res. 7:357-366(2000) [PubMed] [Europe PMC] [Abstract]
  2. "Identification and characterization of three new components of the mSin3A corepressor complex."Mol. Cell. Biol. 23:3456-3467(2003) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] and Placenta.
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] and Spleen.
  5. "Human Sin3 deacetylase and trithorax-related Set1/Ash2 histone H3-K4 methyltransferase are tethered together selectively by the cell-proliferation factor HCF-1."Genes Dev. 17:896-911(2003) [PubMed] [Europe PMC] [Abstract]
  6. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  7. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  8. "Large-scale phosphoproteome analysis of human liver tissue by enrichment and fractionation of phosphopeptides with strong anion exchange chromatography."Proteomics 8:1346-1361(2008) [PubMed] [Europe PMC] [Abstract]
  9. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  10. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  11. "Lys-63-specific deubiquitination of SDS3 by USP17 regulates HDAC activity."J. Biol. Chem. 286:10505-10514(2011) [PubMed] [Europe PMC] [Abstract]
  12. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  13. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]