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RAB4A, Member RAS Oncogene Family (RAB4A)

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HRES-1/RAB4

RAB4A, Member RAS Oncogene Family (RAB4A)
CCC K304
HGNC 9781
MGI 105069
PubMed 11063739
RGD 3529
UniProt P20338
Wiki RAB4A
The mammalian RAB proteins show striking similarities to the S. cerevisiae YPT1 and SEC4 proteins, Ras-related GTP-binding proteins involved in the regulation of secretion. Zahraoui et al. (1989) isolated cDNAs encoding RAB4 and several other human RAB proteins. The predicted 213-amino acid human RAB4 protein shares 98% and 50% identity with rat Rab4 and human RAB2, respectively. Northern blot analysis revealed that the RAB4 gene was expressed weakly as 1.8-, 3.1-, and 3.6-kb mRNAs in a human fibroblast cell line. Barbosa et al. (1995) referred to this locus as RAV4A and mapped the mouse homolog by interspecific backcross analysis to the distal end of mouse chromosome 8. The authors mapped Rab4b to proximal mouse chromosome 7.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant RAB4A, Member RAS Oncogene Family (RAB4A) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to RAB4A, Member RAS Oncogene Family (RAB4A) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to RAB4A, Member RAS Oncogene Family (RAB4A) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for RAB4A, Member RAS Oncogene Family (RAB4A) CLIA Kit Customized Service Offer
n/a ELISA Kit for RAB4A, Member RAS Oncogene Family (RAB4A) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant RAB4A, Member RAS Oncogene Family (RAB4A) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to RAB4A, Member RAS Oncogene Family (RAB4A) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to RAB4A, Member RAS Oncogene Family (RAB4A) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for RAB4A, Member RAS Oncogene Family (RAB4A) CLIA Kit Customized Service Offer
n/a ELISA Kit for RAB4A, Member RAS Oncogene Family (RAB4A) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant RAB4A, Member RAS Oncogene Family (RAB4A) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to RAB4A, Member RAS Oncogene Family (RAB4A) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to RAB4A, Member RAS Oncogene Family (RAB4A) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for RAB4A, Member RAS Oncogene Family (RAB4A) CLIA Kit Customized Service Offer
n/a ELISA Kit for RAB4A, Member RAS Oncogene Family (RAB4A) ELISA Kit Customized Service Offer
  1. "The human Rab genes encode a family of GTP-binding proteins related to yeast YPT1 and SEC4 products involved in secretion."J. Biol. Chem. 264:12394-12401(1989) [PubMed] [Europe PMC] [Abstract]
  2. "Regulation of CD4 expression via recycling by HRES-1/RAB4 controls susceptibility to HIV infection."J. Biol. Chem. 281:34574-34591(2006) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The DNA sequence and biological annotation of human chromosome 1." Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
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  7. "Reversible phosphorylation-dephosphorylation determines the localization of rab4 during the cell cycle."EMBO J. 11:4379-4389(1992) [PubMed] [Europe PMC] [Abstract]
  8. "Rabaptin4, a novel effector of the small GTPase rab4a, is recruited to perinuclear recycling vesicles."Biochem. J. 346:593-601(2000) [PubMed] [Europe PMC] [Abstract]
  9. "Rab coupling protein (RCP), a novel Rab4 and Rab11 effector protein."J. Biol. Chem. 277:12190-12199(2002) [PubMed] [Europe PMC] [Abstract]
  10. "Divalent Rab effectors regulate the sub-compartmental organization and sorting of early endosomes."Nat. Cell Biol. 4:124-133(2002) [PubMed] [Europe PMC] [Abstract]
  11. "Characterisation of the Rab binding properties of Rab coupling protein (RCP) by site-directed mutagenesis."FEBS Lett. 571:86-92(2004) [PubMed] [Europe PMC] [Abstract]
  12. "Rabip4' is an effector of rab5 and rab4 and regulates transport through early endosomes."Mol. Biol. Cell 15:611-624(2004) [PubMed] [Europe PMC] [Abstract]
  13. "The N-Myc down regulated Gene1 (NDRG1) is a Rab4a effector involved in vesicular recycling of E-cadherin."PLoS ONE 2:E844-E844(2007) [PubMed] [Europe PMC] [Abstract]
  14. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  15. "High resolution crystal structures of human Rab4a in its active and inactive conformations."FEBS Lett. 579:2821-2829(2005) [PubMed] [Europe PMC] [Abstract]
  16. "Structural basis of family-wide Rab GTPase recognition by rabenosyn-5."Nature 436:415-419(2005) [PubMed] [Europe PMC] [Abstract]