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RAB7A, Member RAS Oncogene Family (RAB7A)

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RAB7; Ras-related protein Rab-7a

RAB7A, Member RAS Oncogene Family (RAB7A)
CCC K300
HGNC 9788
MGI 105068
PubMed 22072966
RGD 61908
UniProt P51149
Wiki RAB7A
Members of the RAB family of RAS-related GTP-binding proteins are important regulators of vesicular transport and are located in specific intracellular compartments. RAB7 has been localized to late endosomes and shown to be important in the late endocytic pathway. In addition, it has been shown to have a fundamental role in the cellular vacuolation induced by the cytotoxin VacA of Helicobacter pylori.
Various mutations of RAB7A are associated with Hereditary sensory neuropathy type 1C (HSN IC), also known as Charcot-Marie-Tooth syndrome type 2B (CMT2B).The RAB7 cDNA encodes a 207-amino acid protein whose sequence is 99% identical to those of mouse, rat, and dog Rab7 and 61% identical to that of yeast Rab7.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPK300Hu01 Recombinant RAB7A, Member RAS Oncogene Family (RAB7A) Positive Control; Immunogen; SDS-PAGE; WB.
RPK300Hu02 Recombinant RAB7A, Member RAS Oncogene Family (RAB7A) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to RAB7A, Member RAS Oncogene Family (RAB7A) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to RAB7A, Member RAS Oncogene Family (RAB7A) Polyclonal Antibody Customized Service Offer
Assay Kits SEK300Hu ELISA Kit for RAB7A, Member RAS Oncogene Family (RAB7A) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant RAB7A, Member RAS Oncogene Family (RAB7A) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to RAB7A, Member RAS Oncogene Family (RAB7A) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to RAB7A, Member RAS Oncogene Family (RAB7A) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for RAB7A, Member RAS Oncogene Family (RAB7A) CLIA Kit Customized Service Offer
n/a ELISA Kit for RAB7A, Member RAS Oncogene Family (RAB7A) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant RAB7A, Member RAS Oncogene Family (RAB7A) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to RAB7A, Member RAS Oncogene Family (RAB7A) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to RAB7A, Member RAS Oncogene Family (RAB7A) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for RAB7A, Member RAS Oncogene Family (RAB7A) CLIA Kit Customized Service Offer
n/a ELISA Kit for RAB7A, Member RAS Oncogene Family (RAB7A) ELISA Kit Customized Service Offer
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  8. "Human VPS34 and p150 are Rab7 interacting partners."Traffic 4:754-771(2003) [PubMed] [Europe PMC] [Abstract]
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  10. "A unique region of RILP distinguishes it from its related proteins in its regulation of lysosomal morphology and interaction with Rab7 and Rab34."Mol. Biol. Cell 15:815-826(2004) [PubMed] [Europe PMC] [Abstract]
  11. "The oxysterol-binding protein homologue ORP1L interacts with Rab7 and alters functional properties of late endocytic compartments."Mol. Biol. Cell 16:5480-5492(2005) [PubMed] [Europe PMC] [Abstract]
  12. "Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes."J. Proteome Res. 5:3135-3144(2006) [PubMed] [Europe PMC] [Abstract]
  13. "Novel RING E3 ubiquitin ligases in breast cancer."Neoplasia 8:689-695(2006) [PubMed] [Europe PMC] [Abstract]
  14. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
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  16. "FYCO1 is a Rab7 effector that binds to LC3 and PI3P to mediate microtubule plus end-directed vesicle transport."J. Cell Biol. 188:253-269(2010) [PubMed] [Europe PMC] [Abstract]
  17. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  18. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  19. "Rab7: role of its protein interaction cascades in endo-lysosomal traffic."Cell. Signal. 23:516-521(2011) [PubMed] [Europe PMC] [Abstract]
  20. "Rab GTPases regulating phagosome maturation are differentially recruited to mycobacterial phagosomes."Traffic 12:407-420(2011) [PubMed] [Europe PMC] [Abstract]
  21. "Neuronal ceroid lipofuscinosis protein CLN3 interacts with motor proteins and modifies location of late endosomal compartments."Cell. Mol. Life Sci. 69:2075-2089(2012) [PubMed] [Europe PMC] [Abstract]
  22. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  23. "Structural basis for recruitment of RILP by small GTPase Rab7."EMBO J. 24:1491-1501(2005) [PubMed] [Europe PMC] [Abstract]
  24. "Disease mutations in Rab7 result in unregulated nucleotide exchange and inappropriate activation."Hum. Mol. Genet. 19:1033-1047(2010) [PubMed] [Europe PMC] [Abstract]
  25. "Mutations in the small GTP-ase late endosomal protein RAB7 cause Charcot-Marie-Tooth type 2B neuropathy."Am. J. Hum. Genet. 72:722-727(2003) [PubMed] [Europe PMC] [Abstract]
  26. "A novel RAB7 mutation associated with ulcero-mutilating neuropathy."Ann. Neurol. 56:586-590(2004) [PubMed] [Europe PMC] [Abstract]
  27. "Charcot-Marie-Tooth disease due to a de novo mutation of the RAB7 gene."Neurology 67:1476-1478(2006) [PubMed] [Europe PMC] [Abstract]
  28. "Rab7 mutants associated with Charcot-Marie-Tooth disease exhibit enhanced NGF-stimulated signaling."PLoS ONE 5:E15351-E15351(2010) [PubMed] [Europe PMC] [Abstract]