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WD Repeat Containing Domain Protein 77 (WDR77)

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MEP50; Methylosome Protein 50; Androgen receptor cofactor p44

WD Repeat Containing Domain Protein 77 (WDR77)
CCC K294
HGNC 29652
MGI 1917715
PubMed 21789256
RGD 1310479
UniProt Q9BQA1
Wiki WDR77
WDR77 is a component of the 20S PRMT5-containing methyltransferase complex, which modifies specific arginines to dimethylarginines in several spliceosomal Sm proteins . This modification targets Sm proteins to the survival of motor neurons (SMN) complex for assembly into small nuclear ribonucleoprotein core particles .
The deduced 342-amino acid protein has 6 WD repeats and has a calculated molecular mass of 36.7 kD. MEP50 had an apparent molecular mass of 50 kD.Protein pull-down assays revealed that MEP50 specifically interacted with SmB (SNRPB) and SmD2 (SNRPD2) and more weakly with SmD3 (SNRPD3) and SmE (SNRPE). Antibodies directed against MEP50 significantly reduced the arginine methyltransferase activity of the immunopurified complex toward Sm substrates.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant WD Repeat Containing Domain Protein 77 (WDR77) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to WD Repeat Containing Domain Protein 77 (WDR77) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to WD Repeat Containing Domain Protein 77 (WDR77) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for WD Repeat Containing Domain Protein 77 (WDR77) CLIA Kit Customized Service Offer
n/a ELISA Kit for WD Repeat Containing Domain Protein 77 (WDR77) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant WD Repeat Containing Domain Protein 77 (WDR77) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to WD Repeat Containing Domain Protein 77 (WDR77) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to WD Repeat Containing Domain Protein 77 (WDR77) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for WD Repeat Containing Domain Protein 77 (WDR77) CLIA Kit Customized Service Offer
n/a ELISA Kit for WD Repeat Containing Domain Protein 77 (WDR77) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant WD Repeat Containing Domain Protein 77 (WDR77) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to WD Repeat Containing Domain Protein 77 (WDR77) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to WD Repeat Containing Domain Protein 77 (WDR77) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for WD Repeat Containing Domain Protein 77 (WDR77) CLIA Kit Customized Service Offer
n/a ELISA Kit for WD Repeat Containing Domain Protein 77 (WDR77) ELISA Kit Customized Service Offer
  1. "A novel WD repeat protein component of the methylosome binds Sm proteins."J. Biol. Chem. 277:8243-8247(2002) [PubMed] [Europe PMC] [Abstract]
  2. "Purification and identification of a novel complex which is involved in androgen receptor-dependent transcription."Mol. Cell. Biol. 23:7019-7029(2003) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Expression profiling and differential screening between hepatoblastomas and the corresponding normal livers: identification of high expression of the PLK1 oncogene as a poor-prognostic indicator of hepatoblastomas."Oncogene 23:5901-5911(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The DNA sequence and biological annotation of human chromosome 1." Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]