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RAD17 Homolog (RAD17)

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Rad24; RAD17Sp; CCYC; R24L; Cell cycle checkpoint protein RAD17; RF-C/activator 1 homolog

RAD17 Homolog (RAD17)
CCC K282
HGNC 9807
MGI 1333807
PubMed 16885023
RGD 1309515
UniProt O75943
Wiki RAD17
RAD17 is highly similar to the gene product of Schizosaccharomyces pombe rad17, a cell cycle checkpoint gene required for cell cycle arrest and DNA damage repair in response to DNA damage. This protein shares strong similarity with DNA replication factor C (RFC), and can form a complex with RFCs. This protein binds to chromatin prior to DNA damage and is phosphorylated by the checkpoint kinase ATR following damage. This protein recruits the RAD1-RAD9-HUS1 checkpoint protein complex onto chromatin after DNA damage, which may be required for its phosphorylation. The phosphorylation of this protein is required for the DNA-damage-induced cell cycle G2 arrest, and is thought to be a critical early event during checkpoint signaling in DNA-damaged cells.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant RAD17 Homolog (RAD17) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to RAD17 Homolog (RAD17) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to RAD17 Homolog (RAD17) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for RAD17 Homolog (RAD17) CLIA Kit Customized Service Offer
n/a ELISA Kit for RAD17 Homolog (RAD17) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant RAD17 Homolog (RAD17) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to RAD17 Homolog (RAD17) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to RAD17 Homolog (RAD17) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for RAD17 Homolog (RAD17) CLIA Kit Customized Service Offer
n/a ELISA Kit for RAD17 Homolog (RAD17) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant RAD17 Homolog (RAD17) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to RAD17 Homolog (RAD17) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to RAD17 Homolog (RAD17) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for RAD17 Homolog (RAD17) CLIA Kit Customized Service Offer
n/a ELISA Kit for RAD17 Homolog (RAD17) ELISA Kit Customized Service Offer
  1. "cDNA cloning and gene mapping of human homologs for Schizosaccharomyces pombe rad17, rad1, and hus1 and cloning of homologs from mouse, Caenorhabditis elegans, and Drosophila melanogaster."Genomics 54:424-436(1998) [PubMed] [Europe PMC] [Abstract]
  2. "Identification of a human homologue of the Schizosaccharomyces pombe rad17+ checkpoint gene."J. Biol. Chem. 273:18340-18346(1998) [PubMed] [Europe PMC] [Abstract]
  3. ErratumJ. Biol. Chem. 274:24438-24438(1999)
  4. "HRad17, a human homologue of the Schizosaccharomyces pombe checkpoint gene rad17, is overexpressed in colon carcinoma."Cancer Res. 59:2023-2028(1999) [PubMed] [Europe PMC] [Abstract]
  5. "Human and mouse homologs of the Schizosaccharomyces pombe rad17+ cell cycle checkpoint control gene."Genomics 55:219-228(1999) [PubMed] [Europe PMC] [Abstract]
  6. "Human and mouse RAD17 genes: identification, localization, genomic structure and histological expression pattern in normal testis and seminoma."Hum. Genet. 105:17-27(1999) [PubMed] [Europe PMC] [Abstract]
  7. "hRAD17, a structural homolog of the Schizosaccharomyces pombe RAD17 cell cycle checkpoint gene, stimulates p53 accumulation."Oncogene 18:1689-1699(1999) [PubMed] [Europe PMC] [Abstract]
  8. "Human hR24L gene is involved in DNA excision repair and recombination repair."Zhonghua Yi Xue Za Zhi 79:941-943(1999) [PubMed] [Europe PMC] [Abstract]
  9. "Multiple alternative splicing forms of human RAD17 and their differential response to ionizing radiation."Gene 277:145-152(2001) [PubMed] [Europe PMC] [Abstract]
  10. "Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs." Genome Res. 11:422-435(2001) [PubMed] [Europe PMC] [Abstract]
  11. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  12. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  13. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  14. "HRad17 colocalizes with NHP2L1 in the nucleolus and redistributes after UV irradiation."J. Biol. Chem. 274:36544-36549(1999) [PubMed] [Europe PMC] [Abstract]
  15. "The human checkpoint protein hRad17 interacts with the PCNA-like proteins hRad1, hHus1, and hRad9."J. Biol. Chem. 275:29767-29771(2000) [PubMed] [Europe PMC] [Abstract]
  16. "ATR/ATM-mediated phosphorylation of human Rad17 is required for genotoxic stress responses."Nature 411:969-974(2001) [PubMed] [Europe PMC] [Abstract]
  17. "Purification and characterization of human DNA damage checkpoint Rad complexes."Proc. Natl. Acad. Sci. U.S.A. 98:11236-11241(2001) [PubMed] [Europe PMC] [Abstract]
  18. "Phosphorylation of serines 635 and 645 of human Rad17 is cell cycle regulated and is required for G(1)/S checkpoint activation in response to DNA damage."Proc. Natl. Acad. Sci. U.S.A. 98:13102-13107(2001) [PubMed] [Europe PMC] [Abstract]
  19. "Regulation of ATR substrate selection by Rad17-dependent loading of Rad9 complexes onto chromatin."Genes Dev. 16:198-208(2002) [PubMed] [Europe PMC] [Abstract]
  20. "Colocalization of human Rad17 and PCNA in late S phase of the cell cycle upon replication block."Oncogene 21:7710-7719(2002) [PubMed] [Europe PMC] [Abstract]
  21. "Genomic instability and endoreduplication triggered by RAD17 deletion."Genes Dev. 17:965-970(2003) [PubMed] [Europe PMC] [Abstract]
  22. "Identification and characterization of RAD9B, a paralog of the RAD9 checkpoint gene."Genomics 82:644-651(2003) [PubMed] [Europe PMC] [Abstract]
  23. "The human checkpoint Rad protein Rad17 is chromatin-associated throughout the cell cycle, localizes to DNA replication sites, and interacts with DNA polymerase epsilon."Nucleic Acids Res. 31:5568-5575(2003) [PubMed] [Europe PMC] [Abstract]
  24. "Biochemical characterization of DNA damage checkpoint complexes: clamp loader and clamp complexes with specificity for 5' recessed DNA."PLoS Biol. 1:231-243(2003) [PubMed] [Europe PMC] [Abstract]
  25. "Loading of the human 9-1-1 checkpoint complex onto DNA by the checkpoint clamp loader hRad17-replication factor C complex in vitro."Proc. Natl. Acad. Sci. U.S.A. 100:1633-1638(2003) [PubMed] [Europe PMC] [Abstract]
  26. "Requirement of protein phosphatase 5 in DNA-damage-induced ATM activation."Genes Dev. 18:249-254(2004) [PubMed] [Europe PMC] [Abstract]
  27. "Interaction between human MCM7 and Rad17 proteins is required for replication checkpoint signaling."EMBO J. 23:4660-4669(2004) [PubMed] [Europe PMC] [Abstract]
  28. "Chromatin association of rad17 is required for an ataxia telangiectasia and rad-related kinase-mediated S-phase checkpoint in response to low-dose ultraviolet radiation."Mol. Cancer Res. 2:362-369(2004) [PubMed] [Europe PMC] [Abstract]
  29. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  30. "A DNA damage response screen identifies RHINO, a 9-1-1 and TopBP1 interacting protein required for ATR signaling."Science 332:1313-1317(2011) [PubMed] [Europe PMC] [Abstract]