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SWI/SNF Related, Matrix Associated, Actin Dependent Regulator Of Chromatin, Subfamily E, Member 1 (SMARCE1)

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BAF57; BRG1-associated factor 57

SWI/SNF Related, Matrix Associated, Actin Dependent Regulator Of Chromatin, Subfamily E, Member 1 (SMARCE1)
CCC K272
HGNC 11109
MGI 1927347
PubMed 23377182
RGD 1304726
UniProt Q969G3
Wiki SMARCE1
SMARCE1 is part of the large ATP-dependent chromatin remodeling complex SWI/SNF, which is required for transcriptional activation of genes normally repressed by chromatin. The encoded protein, either alone or when in the SWI/SNF complex, can bind to 4-way junction DNA, which is thought to mimic the topology of DNA as it enters or exits the nucleosome. The protein contains a DNA-binding HMG domain, but disruption of this domain does not abolish the DNA-binding or nucleosome-displacement activities of the SWI/SNF complex. Unlike most of the SWI/SNF complex proteins, this protein has no yeast counterpart.The predicted 411-amino acid protein contains an HMG domain adjacent to a kinesin-like region. RNase protection studies and Western blot analysis revealed that BAF57 is expressed ubiquitously.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant SWI/SNF Related, Matrix Associated, Actin Dependent Regulator Of Chromatin, Subfamily E, Member 1 (SMARCE1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to SWI/SNF Related, Matrix Associated, Actin Dependent Regulator Of Chromatin, Subfamily E, Member 1 (SMARCE1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to SWI/SNF Related, Matrix Associated, Actin Dependent Regulator Of Chromatin, Subfamily E, Member 1 (SMARCE1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for SWI/SNF Related, Matrix Associated, Actin Dependent Regulator Of Chromatin, Subfamily E, Member 1 (SMARCE1) CLIA Kit Customized Service Offer
n/a ELISA Kit for SWI/SNF Related, Matrix Associated, Actin Dependent Regulator Of Chromatin, Subfamily E, Member 1 (SMARCE1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant SWI/SNF Related, Matrix Associated, Actin Dependent Regulator Of Chromatin, Subfamily E, Member 1 (SMARCE1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to SWI/SNF Related, Matrix Associated, Actin Dependent Regulator Of Chromatin, Subfamily E, Member 1 (SMARCE1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to SWI/SNF Related, Matrix Associated, Actin Dependent Regulator Of Chromatin, Subfamily E, Member 1 (SMARCE1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for SWI/SNF Related, Matrix Associated, Actin Dependent Regulator Of Chromatin, Subfamily E, Member 1 (SMARCE1) CLIA Kit Customized Service Offer
n/a ELISA Kit for SWI/SNF Related, Matrix Associated, Actin Dependent Regulator Of Chromatin, Subfamily E, Member 1 (SMARCE1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant SWI/SNF Related, Matrix Associated, Actin Dependent Regulator Of Chromatin, Subfamily E, Member 1 (SMARCE1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to SWI/SNF Related, Matrix Associated, Actin Dependent Regulator Of Chromatin, Subfamily E, Member 1 (SMARCE1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to SWI/SNF Related, Matrix Associated, Actin Dependent Regulator Of Chromatin, Subfamily E, Member 1 (SMARCE1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for SWI/SNF Related, Matrix Associated, Actin Dependent Regulator Of Chromatin, Subfamily E, Member 1 (SMARCE1) CLIA Kit Customized Service Offer
n/a ELISA Kit for SWI/SNF Related, Matrix Associated, Actin Dependent Regulator Of Chromatin, Subfamily E, Member 1 (SMARCE1) ELISA Kit Customized Service Offer
  1. "Architectural DNA binding by a high-mobility-group/kinesin-like subunit in mammalian SWI/SNF-related complexes."Proc. Natl. Acad. Sci. U.S.A. 95:492-498(1998) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage." Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "REST repression of neuronal genes requires components of the hSWI.SNF complex."J. Biol. Chem. 277:41038-41045(2002) [PubMed] [Europe PMC] [Abstract]
  6. "Reciprocal regulation of CD4/CD8 expression by SWI/SNF-like BAF complexes."Nature 418:195-199(2002) [PubMed] [Europe PMC] [Abstract]
  7. "Targeting of SWI/SNF chromatin remodelling complexes to estrogen-responsive genes."EMBO J. 21:4094-4103(2002) [PubMed] [Europe PMC] [Abstract]
  8. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  9. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  10. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  11. "Recent advances in understanding chromatin remodeling by SWI/SNF complexes."Curr. Opin. Genet. Dev. 13:136-142(2003) [PubMed] [Europe PMC] [Abstract]
  12. "BAF60a mediates critical interactions between nuclear receptors and the BRG1 chromatin-remodeling complex for transactivation."Mol. Cell. Biol. 23:6210-6220(2003) [PubMed] [Europe PMC] [Abstract]
  13. "hZimp7, a novel PIAS-like protein, enhances androgen receptor-mediated transcription and interacts with SWI/SNF-like BAF complexes."Mol. Endocrinol. 19:2915-2929(2005) [PubMed] [Europe PMC] [Abstract]
  14. "Regulation of muscle development by DPF3, a novel histone acetylation and methylation reader of the BAF chromatin remodeling complex."Genes Dev. 22:2370-2384(2008) [PubMed] [Europe PMC] [Abstract]
  15. "Ubiquitin-dependent and ubiquitin-independent control of subunit stoichiometry in the SWI/SNF complex."J. Biol. Chem. 285:35665-35674(2010) [PubMed] [Europe PMC] [Abstract]
  16. "Mutations affecting components of the SWI/SNF complex cause Coffin-Siris syndrome." Nat. Genet. 44:376-378(2012) [PubMed] [Europe PMC] [Abstract]
  17. "Loss-of-function mutations in SMARCE1 cause an inherited disorder of multiple spinal meningiomas."Nat. Genet. 45:295-298(2013) [PubMed] [Europe PMC] [Abstract]
  18. "Pediatric intracranial clear cell meningioma associated with a germline mutation of SMARCE1: a novel case."Childs Nerv. Syst. 31:441-447(2015) [PubMed] [Europe PMC] [Abstract]