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SWI/SNF Related, Matrix Associated, Actin Dependent Regulator Of Chromatin, Subfamily B, Member 1 (SMARCB1)

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SNF5L1; BAF47; Ini1; Snr1; hSNFS; Sfh1p; RDT; Sucrose Nonfermenting,Yeast,Homolog-Like 1; Integrase Interactor 1; Malignant Rhabdoid Tumor Suppressor

SWI/SNF Related, Matrix Associated, Actin Dependent Regulator Of Chromatin, Subfamily B, Member 1 (SMARCB1)
CCC K269
HGNC 11103
MGI 1328366
PubMed 15899790
RGD 1308761
UniProt Q12824
Wiki SMARCB1
SMARCB1 is a subunit of the SWI/SNF ATP-dependent chromatin-remodeling complex. Mutation in the SMARCB1 gene can result in rhabdoid tumors, atypical teratoid tumors, and familial posterior fossa tumors of infancy .
SNF5 could bind independently with the protein phosphatase-1 (PP1) catalytic subunit (PPP1CA) and stimulate its activity in solution and in complex with GADD34. SNF5 and PP1 did not compete for GADD34 binding, but rather formed a stable trimeric complex with GADD34.Reexpression of SNF5 restored the coupling between cell cycle progression and ploidy checkpoints. In contrast, cancer-associated SNF5 mutations exacerbated poly- and aneuploidization by abrogating chromosome segregation.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant SWI/SNF Related, Matrix Associated, Actin Dependent Regulator Of Chromatin, Subfamily B, Member 1 (SMARCB1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to SWI/SNF Related, Matrix Associated, Actin Dependent Regulator Of Chromatin, Subfamily B, Member 1 (SMARCB1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to SWI/SNF Related, Matrix Associated, Actin Dependent Regulator Of Chromatin, Subfamily B, Member 1 (SMARCB1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for SWI/SNF Related, Matrix Associated, Actin Dependent Regulator Of Chromatin, Subfamily B, Member 1 (SMARCB1) CLIA Kit Customized Service Offer
n/a ELISA Kit for SWI/SNF Related, Matrix Associated, Actin Dependent Regulator Of Chromatin, Subfamily B, Member 1 (SMARCB1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant SWI/SNF Related, Matrix Associated, Actin Dependent Regulator Of Chromatin, Subfamily B, Member 1 (SMARCB1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to SWI/SNF Related, Matrix Associated, Actin Dependent Regulator Of Chromatin, Subfamily B, Member 1 (SMARCB1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to SWI/SNF Related, Matrix Associated, Actin Dependent Regulator Of Chromatin, Subfamily B, Member 1 (SMARCB1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for SWI/SNF Related, Matrix Associated, Actin Dependent Regulator Of Chromatin, Subfamily B, Member 1 (SMARCB1) CLIA Kit Customized Service Offer
n/a ELISA Kit for SWI/SNF Related, Matrix Associated, Actin Dependent Regulator Of Chromatin, Subfamily B, Member 1 (SMARCB1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant SWI/SNF Related, Matrix Associated, Actin Dependent Regulator Of Chromatin, Subfamily B, Member 1 (SMARCB1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to SWI/SNF Related, Matrix Associated, Actin Dependent Regulator Of Chromatin, Subfamily B, Member 1 (SMARCB1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to SWI/SNF Related, Matrix Associated, Actin Dependent Regulator Of Chromatin, Subfamily B, Member 1 (SMARCB1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for SWI/SNF Related, Matrix Associated, Actin Dependent Regulator Of Chromatin, Subfamily B, Member 1 (SMARCB1) CLIA Kit Customized Service Offer
n/a ELISA Kit for SWI/SNF Related, Matrix Associated, Actin Dependent Regulator Of Chromatin, Subfamily B, Member 1 (SMARCB1) ELISA Kit Customized Service Offer
  1. "Binding and stimulation of HIV-1 integrase by a human homolog of yeast transcription factor SNF5."Science 266:2002-2006(1994) [PubMed] [Europe PMC] [Abstract]
  2. "Truncating mutations of hSNF5/INI1 in aggressive paediatric cancer."Nature 394:203-206(1998) [PubMed] [Europe PMC] [Abstract]
  3. "The mouse ortholog of the human SMARCB1 gene encodes two splice forms."Biochem. Biophys. Res. Commun. 257:886-890(1999) [PubMed] [Europe PMC] [Abstract]
  4. "A genome annotation-driven approach to cloning the human ORFeome."Genome Biol. 5:R84.1-R84.11(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Purification and biochemical heterogeneity of the mammalian SWI-SNF complex."EMBO J. 15:5370-5382(1996) [PubMed] [Europe PMC] [Abstract]
  8. "Epstein-Barr virus nuclear protein 2 (EBNA2) binds to a component of the human SNF-SWI complex, hSNF5/Ini1."J. Virol. 70:6020-6028(1996) [PubMed] [Europe PMC] [Abstract]
  9. "Structure-function analysis of integrase interactor 1/hSNF5L1 reveals differential properties of two repeat motifs present in the highly conserved region."Proc. Natl. Acad. Sci. U.S.A. 95:1120-1125(1998) [PubMed] [Europe PMC] [Abstract]
  10. "Leukemic HRX fusion proteins inhibit GADD34-induced apoptosis and associate with the GADD34 and hSNF5/INI1 proteins."Mol. Cell. Biol. 19:7050-7060(1999) [PubMed] [Europe PMC] [Abstract]
  11. "c-MYC interacts with INI1/hSNF5 and requires the SWI/SNF complex for transactivation function."Nat. Genet. 22:102-105(1999) [PubMed] [Europe PMC] [Abstract]
  12. "Interaction of E1 and hSNF5 proteins stimulates replication of human papillomavirus DNA."Nature 399:487-491(1999) [PubMed] [Europe PMC] [Abstract]
  13. "Reconstitution of a core chromatin remodeling complex from SWI/SNF subunits."Mol. Cell 3:247-253(1999) [PubMed] [Europe PMC] [Abstract]
  14. "Germ-line and acquired mutations of INI1 in atypical teratoid and rhabdoid tumors."Cancer Res. 59:74-79(1999) [PubMed] [Europe PMC] [Abstract]
  15. "The human SNF5/INI1 protein facilitates the function of the growth arrest and DNA damage-inducible protein (GADD34) and modulates GADD34-bound protein phosphatase-1 activity."J. Biol. Chem. 277:27706-27715(2002) [PubMed] [Europe PMC] [Abstract]
  16. "A key role of the hSNF5/INI1 tumour suppressor in the control of the G1-S transition of the cell cycle."Oncogene 21:6403-6412(2002) [PubMed] [Europe PMC] [Abstract]
  17. "P16INK4a is required for hSNF5 chromatin remodeler-induced cellular senescence in malignant rhabdoid tumor cells."J. Biol. Chem. 279:3807-3816(2004) [PubMed] [Europe PMC] [Abstract]
  18. "Chromatin-remodeling factor INI1/hSNF5/BAF47 is involved in activation of the colony stimulating factor 1 promoter."Mol. Cells 20:183-188(2005) [PubMed] [Europe PMC] [Abstract]
  19. "SMARCB1/INI1 tumor suppressor gene is frequently inactivated in epithelioid sarcomas."Cancer Res. 65:4012-4019(2005) [PubMed] [Europe PMC] [Abstract]
  20. "ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage."Science 316:1160-1166(2007) [PubMed] [Europe PMC] [Abstract]
  21. "Crosstalk between C/EBPbeta phosphorylation, arginine methylation, and SWI/SNF/Mediator implies an indexing transcription factor code."EMBO J. 29:1105-1115(2010) [PubMed] [Europe PMC] [Abstract]
  22. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  23. "Human SWI/SNF generates abundant, structurally altered dinucleosomes on polynucleosomal templates."Mol. Cell. Biol. 25:11156-11170(2005) [PubMed] [Europe PMC] [Abstract]
  24. "Regulation of muscle development by DPF3, a novel histone acetylation and methylation reader of the BAF chromatin remodeling complex."Genes Dev. 22:2370-2384(2008) [PubMed] [Europe PMC] [Abstract]
  25. "Germline mutation of INI1/SMARCB1 in familial schwannomatosis."Am. J. Hum. Genet. 80:805-810(2007) [PubMed] [Europe PMC] [Abstract]
  26. "Evidence of a four-hit mechanism involving SMARCB1 and NF2 in schwannomatosis-associated schwannomas."Hum. Mutat. 29:227-231(2008) [PubMed] [Europe PMC] [Abstract]
  27. "Human PIH1 associates with histone H4 to mediate the glucose-dependent enhancement of pre-rRNA synthesis."J. Mol. Cell Biol. 4:231-241(2012) [PubMed] [Europe PMC] [Abstract]
  28. "Mutations affecting components of the SWI/SNF complex cause Coffin-Siris syndrome." Nat. Genet. 44:376-378(2012) [PubMed] [Europe PMC] [Abstract]